No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts

Nicolai A Lund-Blix; Anne A Bjerregaard; German Tapia; Ketil Størdal; Anne Lise Brantsæter; Marin Strøm; Thorhallur I Halldorsson; Charlotta Granstrøm; Jannet Svensson; Geir Joner; Torild Skrivarhaug; Pål R Njølstad; Sjurdur F Olsen; Lars C Stene

doi:10.1007/s00125-024-06125-4

No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts

Nicolai A Lund-Blix, Anne A Bjerregaard, German Tapia, Ketil Størdal, Anne Lise Brantsæter, Marin Strøm, Thorhallur I Halldorsson, Charlotta Granstrøm, Jannet Svensson, Geir Joner, Torild Skrivarhaug, Pål R Njølstad, Sjurdur F Olsen, Lars C Stene

2 Citations (Scopus)

Abstract

AIMS/HYPOTHESIS: The aim of this study was to investigate whether higher dietary intake of marine n-3 fatty acids during pregnancy is associated with a lower risk of type 1 diabetes in children.

METHODS: The Danish National Birth Cohort (DNBC) and the Norwegian Mother, Father and Child Cohort Study (MoBa) together include 153,843 mother-child pairs with prospectively collected data on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake during pregnancy from validated food frequency questionnaires. Type 1 diabetes diagnosis in children (n=634) was ascertained from national diabetes registries.

RESULTS: There was no association between the sum of EPA and DHA intake during pregnancy and risk of type 1 diabetes in offspring (pooled HR per g/day of intake: 1.00, 95% CI 0.88, 1.14), with consistent results for both the MoBa and the DNBC. Robustness analyses gave very similar results.

CONCLUSIONS/INTERPRETATION: Initiation of a trial of EPA and DHA during pregnancy to prevent type 1 diabetes in offspring should not be prioritised.

Original language	English
Journal	Diabetologia
Volume	67
Issue number	6
Pages (from-to)	1023-1028
Number of pages	6
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-024-06125-4
Publication status	Published - Jun 2024

Keywords

Adult
Child
Cohort Studies
Denmark/epidemiology
Diabetes Mellitus, Type 1/epidemiology
Docosahexaenoic Acids/administration & dosage
Eicosapentaenoic Acid/administration & dosage
Fatty Acids, Omega-3/administration & dosage
Female
Humans
Male
Norway/epidemiology
Pregnancy
Prenatal Exposure Delayed Effects/epidemiology
Risk Factors
Human
Intrauterine nutrition
Nutrition
Maternal and child health
Type 1 diabetes
Child health
Cohort studies

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10.1007/s00125-024-06125-4

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Lund-Blix, N. A., Bjerregaard, A. A., Tapia, G., Størdal, K., Brantsæter, A. L., Strøm, M., Halldorsson, T. I., Granstrøm, C., Svensson, J., Joner, G., Skrivarhaug, T., Njølstad, P. R., Olsen, S. F., & Stene, L. C. (2024). No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts. Diabetologia, 67(6), 1023-1028. https://doi.org/10.1007/s00125-024-06125-4

No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts. / Lund-Blix, Nicolai A; Bjerregaard, Anne A; Tapia, German et al.
In: Diabetologia, Vol. 67, No. 6, 06.2024, p. 1023-1028.

Research output: Contribution to journal › Journal article › Research › peer-review

Lund-Blix, NA, Bjerregaard, AA, Tapia, G, Størdal, K, Brantsæter, AL, Strøm, M, Halldorsson, TI, Granstrøm, C, Svensson, J, Joner, G, Skrivarhaug, T, Njølstad, PR, Olsen, SF & Stene, LC 2024, 'No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts', Diabetologia, vol. 67, no. 6, pp. 1023-1028. https://doi.org/10.1007/s00125-024-06125-4

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title = "No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts",

abstract = "AIMS/HYPOTHESIS: The aim of this study was to investigate whether higher dietary intake of marine n-3 fatty acids during pregnancy is associated with a lower risk of type 1 diabetes in children.METHODS: The Danish National Birth Cohort (DNBC) and the Norwegian Mother, Father and Child Cohort Study (MoBa) together include 153,843 mother-child pairs with prospectively collected data on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake during pregnancy from validated food frequency questionnaires. Type 1 diabetes diagnosis in children (n=634) was ascertained from national diabetes registries.RESULTS: There was no association between the sum of EPA and DHA intake during pregnancy and risk of type 1 diabetes in offspring (pooled HR per g/day of intake: 1.00, 95\% CI 0.88, 1.14), with consistent results for both the MoBa and the DNBC. Robustness analyses gave very similar results.CONCLUSIONS/INTERPRETATION: Initiation of a trial of EPA and DHA during pregnancy to prevent type 1 diabetes in offspring should not be prioritised.",

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author = "Lund-Blix, \{Nicolai A\} and Bjerregaard, \{Anne A\} and German Tapia and Ketil St{\o}rdal and Brants{\ae}ter, \{Anne Lise\} and Marin Str{\o}m and Halldorsson, \{Thorhallur I\} and Charlotta Granstr{\o}m and Jannet Svensson and Geir Joner and Torild Skrivarhaug and Nj{\o}lstad, \{P{\aa}l R\} and Olsen, \{Sjurdur F\} and Stene, \{Lars C\}",

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year = "2024",

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doi = "10.1007/s00125-024-06125-4",

language = "English",

volume = "67",

pages = "1023--1028",

journal = "Diabetologia",

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TY - JOUR

T1 - No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts

AU - Lund-Blix, Nicolai A

AU - Bjerregaard, Anne A

AU - Tapia, German

AU - Størdal, Ketil

AU - Brantsæter, Anne Lise

AU - Strøm, Marin

AU - Halldorsson, Thorhallur I

AU - Granstrøm, Charlotta

AU - Svensson, Jannet

AU - Joner, Geir

AU - Skrivarhaug, Torild

AU - Njølstad, Pål R

AU - Olsen, Sjurdur F

AU - Stene, Lars C

PY - 2024/6

Y1 - 2024/6

N2 - AIMS/HYPOTHESIS: The aim of this study was to investigate whether higher dietary intake of marine n-3 fatty acids during pregnancy is associated with a lower risk of type 1 diabetes in children.METHODS: The Danish National Birth Cohort (DNBC) and the Norwegian Mother, Father and Child Cohort Study (MoBa) together include 153,843 mother-child pairs with prospectively collected data on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake during pregnancy from validated food frequency questionnaires. Type 1 diabetes diagnosis in children (n=634) was ascertained from national diabetes registries.RESULTS: There was no association between the sum of EPA and DHA intake during pregnancy and risk of type 1 diabetes in offspring (pooled HR per g/day of intake: 1.00, 95% CI 0.88, 1.14), with consistent results for both the MoBa and the DNBC. Robustness analyses gave very similar results.CONCLUSIONS/INTERPRETATION: Initiation of a trial of EPA and DHA during pregnancy to prevent type 1 diabetes in offspring should not be prioritised.

AB - AIMS/HYPOTHESIS: The aim of this study was to investigate whether higher dietary intake of marine n-3 fatty acids during pregnancy is associated with a lower risk of type 1 diabetes in children.METHODS: The Danish National Birth Cohort (DNBC) and the Norwegian Mother, Father and Child Cohort Study (MoBa) together include 153,843 mother-child pairs with prospectively collected data on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake during pregnancy from validated food frequency questionnaires. Type 1 diabetes diagnosis in children (n=634) was ascertained from national diabetes registries.RESULTS: There was no association between the sum of EPA and DHA intake during pregnancy and risk of type 1 diabetes in offspring (pooled HR per g/day of intake: 1.00, 95% CI 0.88, 1.14), with consistent results for both the MoBa and the DNBC. Robustness analyses gave very similar results.CONCLUSIONS/INTERPRETATION: Initiation of a trial of EPA and DHA during pregnancy to prevent type 1 diabetes in offspring should not be prioritised.

KW - Adult

KW - Child

KW - Cohort Studies

KW - Denmark/epidemiology

KW - Diabetes Mellitus, Type 1/epidemiology

KW - Docosahexaenoic Acids/administration & dosage

KW - Eicosapentaenoic Acid/administration & dosage

KW - Fatty Acids, Omega-3/administration & dosage

KW - Female

KW - Humans

KW - Male

KW - Norway/epidemiology

KW - Pregnancy

KW - Prenatal Exposure Delayed Effects/epidemiology

KW - Risk Factors

KW - Human

KW - Intrauterine nutrition

KW - Nutrition

KW - Maternal and child health

KW - Type 1 diabetes

KW - Child health

KW - Cohort studies

UR - https://www.scopus.com/pages/publications/85188101639

U2 - 10.1007/s00125-024-06125-4

DO - 10.1007/s00125-024-06125-4

M3 - Journal article

C2 - 38502240

SN - 0012-186X

VL - 67

SP - 1023

EP - 1028

JO - Diabetologia

JF - Diabetologia

IS - 6

ER -

No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts

Abstract

Keywords

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