Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

No association between early maternal HbA1c and offspring birthweight among women without pre-existing diabetes in Greenland

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Diabetes in Greenland - how to deliver diabetes care in a country with a geographically dispersed population

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Gestational diabetes and macrosomia among Greenlanders. Time to change diagnostic strategy?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Gonorrhoea in Greenland: geographic differences in diagnostic activity and incidence of gonorrhoea in 2015

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Validation of cardiovascular diagnoses in the Greenlandic Hospital Discharge Register for epidemiological use

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Gestational Diabetes Risk in Migrants. A Nationwide, Register-Based Study of all Births in Denmark 2004 to 2015

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Migration, body mass index and gestational diabetes mellitus among women in Denmark 2004-2015: a register-based study

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  3. Migration, body mass index and gestational diabetes mellitus among women in Denmark 2004-2015: a register-based study

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

View graph of relations

Studies of the association between maternal blood glucose measured by glycated haemoglobin (HbA1c) during pregnancy and the offspring's birthweight have been heterogeneous. The aim of this study was to examine the association between maternal HbA1c level before gestational week 20 and the offspring's birthweight among predominantly indigenous women in Greenland. A retrospective cohort study including all women (n = 503) and their offspring delivered from September 2015 to September 2016 at Queen Ingrid's Hospital in Nuuk was conducted. Data were obtained from the electronic medical record. Linear regression models were used to analyse the effect of maternal HbA1c on the offspring's birthweight with adjustment and stratification for relevant confounders and effect modifiers. Birthweight increased with 3.3 g per mmol/mol increase in HbA1c. Yet, no significant association between maternal HbA1c and the offspring's birthweight was found after adjustment for maternal age, ethnicity, residence, smoking, and parity (β = 0.058, p = 0.711). Among obese women, a borderline significant positive association (β = 0.657, p = 0.059) was found. For term newborns, this corresponded to an increase in birthweight of 31 g per mmol/mol increase in HbA1c. Based on the current study, the use of HbA1c during pregnancy to detect the risk of delivering a newborn with macrosomia is not recommended in Greenland.Abbreviation: HbA1c: glycosylated haemoglobin; GA: gestational age; SD: standard deviation; CI: confidence interval.

Original languageEnglish
Article number1702798
JournalInternational Journal of Circumpolar Health
Volume79
Issue number1
ISSN1239-9736
DOIs
Publication statusPublished - 11 Dec 2019

    Research areas

  • birthweight, Glycosylated haemoglobin, Greenland, pregnancy

ID: 58644628