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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Nickel allergy and allergic contact dermatitis: A clinical review of immunology, epidemiology, exposure, and treatment

Research output: Contribution to journalReviewResearchpeer-review

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  1. Allergic contact stomatitis caused by (meth)acrylates in an occlusal splint

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Exposure analysis using X-ray fluorescence device and a cobalt spot test in four patients with cobalt allergy

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  3. Multispectral imaging of hand eczema

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  4. Causative exposures and temporal development of cobalt allergy in Denmark between 2002 and 2017

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  5. Diagnostic workup of occupational allergic nickel dermatitis in a nurse with multiple nickel exposures

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Allergic contact stomatitis caused by (meth)acrylates in an occlusal splint

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Exposure analysis using X-ray fluorescence device and a cobalt spot test in four patients with cobalt allergy

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Systematic review on rapidity of onset of action for interleukin-17 and interleukin-23 inhibitors for psoriasis

    Research output: Contribution to journalReviewResearchpeer-review

  4. Chronologic order of appearance of immune-mediated inflammatory diseases relative to diagnosis of psoriasis

    Research output: Contribution to journalJournal articleResearchpeer-review

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Nickel is the most frequent cause of contact allergy worldwide and has been studied extensively. This clinical review provides an updated overview of the epidemiology, exposure sources, methods for exposure quantification, skin deposition and penetration, immunology, diagnosis, thresholds for sensitization and elicitation, clinical pictures, prevention, and treatment. The implementation of a nickel regulation in Europe led to a decrease in the prevalence of nickel allergy, and changes in the clinical picture and disease severity. Nevertheless, the prevalences of nickel allergy in the European general population are approximately 8% to 19% in adults and 8% to 10% in children and adolescents, with a strong female predominance. Well-known consumer items such as jewellery and metal in clothing are still the main causes of nickel allergy and dermatitis, although a wide range of items for both private and occupational use may cause dermatitis. Allergic nickel dermatitis may be localized to the nickel exposure site, be more widespread, or present as hand eczema. Today, efficient methods for exposure quantification exist, and new insights regarding associated risk factors and immunological mechanisms underlying the disease have been obtained. Nevertheless, questions remain in relation to the pathogenesis, the persistent high prevalence, and the treatment of severe cases.

Original languageEnglish
JournalContact Dermatitis
Volume81
Issue number4
Pages (from-to)227-241
Number of pages15
ISSN0105-1873
DOIs
Publication statusPublished - Oct 2019

ID: 58312272