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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Nickel allergy and allergic contact dermatitis: A clinical review of immunology, epidemiology, exposure, and treatment

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  1. Causative exposures and temporal development of cobalt allergy in Denmark between 2002 and 2017

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Diagnostic workup of occupational allergic nickel dermatitis in a nurse with multiple nickel exposures

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Patch test reactivity to aluminium chambers

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Hand eczema patients' knowledge of skin protection following a guided talk -a retrospective study with a follow-up questionnaire

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  5. Quality of life and disease severity in dermatitis patients with fragrance allergy-A cross-sectional European questionnaire study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Causative exposures and temporal development of cobalt allergy in Denmark between 2002 and 2017

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Diagnostic workup of occupational allergic nickel dermatitis in a nurse with multiple nickel exposures

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Factors associated with patient-reported importance of skin clearance among adults with psoriasis and atopic dermatitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Patch test reactivity to aluminium chambers

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Cytokine Profile in Patients with Aseptic Loosening of Total Hip Replacements and Its Relation to Metal Release and Metal Allergy

    Research output: Contribution to journalJournal articleResearchpeer-review

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Nickel is the most frequent cause of contact allergy worldwide and has been studied extensively. This clinical review provides an updated overview of the epidemiology, exposure sources, methods for exposure quantification, skin deposition and penetration, immunology, diagnosis, thresholds for sensitization and elicitation, clinical pictures, prevention, and treatment. The implementation of a nickel regulation in Europe led to a decrease in the prevalence of nickel allergy, and changes in the clinical picture and disease severity. Nevertheless, the prevalences of nickel allergy in the European general population are approximately 8% to 19% in adults and 8% to 10% in children and adolescents, with a strong female predominance. Well-known consumer items such as jewellery and metal in clothing are still the main causes of nickel allergy and dermatitis, although a wide range of items for both private and occupational use may cause dermatitis. Allergic nickel dermatitis may be localized to the nickel exposure site, be more widespread, or present as hand eczema. Today, efficient methods for exposure quantification exist, and new insights regarding associated risk factors and immunological mechanisms underlying the disease have been obtained. Nevertheless, questions remain in relation to the pathogenesis, the persistent high prevalence, and the treatment of severe cases.

Original languageEnglish
JournalContact Dermatitis
Volume81
Issue number4
Pages (from-to)227-241
Number of pages15
ISSN0105-1873
DOIs
Publication statusPublished - Oct 2019

ID: 58312272