Neutrophils, from marrow to microbes

Niels Borregaard

    1065 Citations (Scopus)

    Abstract

    Neutrophils are produced in the bone marrow from stem cells that proliferate and differentiate to mature neutrophils fully equipped with an armory of granules. These contain proteins that enable the neutrophil to deliver lethal hits against microorganisms, but also to cause great tissue damage. Neutrophils circulate in the blood as dormant cells. At sites of infection, endothelial cells capture bypassing neutrophils and guide them through the endothelial cell lining whereby the neutrophils are activated and tuned for the subsequent interaction with microbes. Once in tissues, neutrophils kill microorganisms by microbicidal agents liberated from granules or generated by metabolic activation. As a final act, neutrophils can extrude stands of DNA with bactericidal proteins attached that act as extracellular traps for microorganisms.
    Original languageEnglish
    JournalImmunity
    Volume33
    Issue number5
    Pages (from-to)657-70
    Number of pages14
    ISSN1074-7613
    DOIs
    Publication statusPublished - 24 Nov 2010

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