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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Neutrophils at work

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Empty peptide-receptive MHC class I molecules for efficient detection of antigen-specific T cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Identification of two distinct pathways of human myelopoiesis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Vitamin D controls T cell antigen receptor signaling and activation of human T cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  • William M Nauseef
  • Niels Borregaard
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In this Review we discuss data demonstrating recently recognized aspects of neutrophil homeostasis in the steady state, granulopoiesis in 'emergency' conditions and interactions of neutrophils with the adaptive immune system. We explore in vivo observations of the recruitment of neutrophils from blood to tissues in models of blood-borne infections versus bacterial invasion through epithelial linings. We examine data on novel aspects of the activation of NADPH oxidase and the heterogeneity of phagosomes and, finally, consider the importance of two neutrophil-derived biological agents: neutrophil extracellular traps and ectosomes.

Original languageEnglish
JournalNature Immunology
Volume15
Issue number7
Pages (from-to)602-11
Number of pages10
ISSN1529-2908
DOIs
Publication statusPublished - Jul 2014

    Research areas

  • Animals, Blood Bactericidal Activity, Blood-Borne Pathogens, Calcium, Cell Movement, Humans, Infection, NADPH Oxidase, Neutrophils, Phagosomes

ID: 45073819