Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Neurosurgical patterns of care for diffuse low-grade gliomas in Sweden between 2005 and 2015

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Shared decision making in high-grade glioma patients—a systematic review

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Return to work following meningioma surgery: a Swedish nationwide registry-based matched cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Psychometric validity and reliability of the Danish version of the MD Anderson Symptom Inventory Brain Tumor Module

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Development of an item bank for computerized adaptive testing of self-reported cognitive difficulty in cancer patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Mitotic and Proliferative Indices in WHO Grade III Meningioma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Preoperative antibiotic prophylaxis regimen in brain tumour surgery in Sweden: a quasi-experimental study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Cost-effectiveness of stereotactic laser ablation (SLA) for brain tumors

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Return to work following meningioma surgery: a Swedish nationwide registry-based matched cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Louise Carstam
  • Anja Smits
  • Peter Milos
  • Alba Corell
  • Roger Henriksson
  • Jiri Bartek
  • Asgeir Store Jakola
View graph of relations

Background: In the last decade, increasing evidence has evolved for early and maximal safe resection of diffuse low-grade gliomas (LGGs) regarding survival. However, changes in clinical practice are known to occur slowly and we do not know if the scientific evidence has yet resulted in changes in neurosurgical patterns of care.

Methods: The Swedish Brain Tumor Registry was used to identify all patients with a first-time histopathological diagnosis of LGG between 2005 and 2015. For analysis of surgical treatment patterns, we subdivided assessed time periods into 2005-2008, 2009-2012, and 2013-2015. Population-based data on patient and disease characteristics, surgical management, and outcomes were extracted.

Results: A total of 548 patients with diffuse World Health Organization grade II gliomas were identified: 142 diagnosed during 2005-2008, 244 during 2009-2012, and 162 during 2013-2015. Resection as opposed to biopsy was performed in 64.3% during 2005-2008, 74.2% during 2009-2012, and 74.1% during 2013-2015 (P = .08). There was no difference among the 3 periods regarding overall survival (P = .11). However, post hoc analysis of data from the 4 (out of 6) centers that covered all 3 time periods demonstrated a resection rate of 64.3% during 2005-2008, 77.4% during 2009-2012, and 75.4% during 2013-2015 (P = .02) and longer survival of patients diagnosed 2009 and onward (P = .04).

Conclusion: In this nationwide, population-based study we observed a shift over time in favor of LGG resection. Further, a positive correlation between the more active surgical strategy and longer survival is shown, although no causality can be claimed because of possible confounding factors.

Original languageEnglish
JournalNeuro-Oncology Practice
Volume6
Issue number2
Pages (from-to)124-133
Number of pages10
ISSN2054-2577
DOIs
Publication statusPublished - Mar 2019

    Research areas

  • diffuse low-grade glioma, glioma/surgery, neurosurgery, patterns of care, treatment outcome

ID: 58587084