Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Neurophysiological basis of rapid eye movement sleep behavior disorder: informing future drug development

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Sleep quality and circadian rhythm disruption in the intensive care unit: a review

    Research output: Contribution to journalReviewResearchpeer-review

  2. Melatonin and cortisol profiles in late midlife and their association with age-related changes in cognition

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Robust, ECG-based detection of Sleep-disordered breathing in large population-based cohorts

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Long-term health and socioeconomic consequences of childhood and adolescent-onset of narcolepsy

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The role of sleep in the pathophysiology of nocturnal enuresis

    Research output: Contribution to journalReviewResearchpeer-review

  4. CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by a history of recurrent nocturnal dream enactment behavior and loss of skeletal muscle atonia and increased phasic muscle activity during REM sleep: REM sleep without atonia. RBD and associated comorbidities have recently been identified as one of the most specific and potentially sensitive risk factors for later development of any of the alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and other atypical parkinsonian syndromes. Several other sleep-related abnormalities have recently been identified in patients with RBD/Parkinson's disease who experience abnormalities in sleep electroencephalographic frequencies, sleep-wake transitions, wake and sleep stability, occurrence and morphology of sleep spindles, and electrooculography measures. These findings suggest a gradual involvement of the brainstem and other structures, which is in line with the gradual involvement known in these disorders. We propose that these findings may help identify biomarkers of individuals at high risk of subsequent conversion to parkinsonism.

Original languageEnglish
JournalNature and Science of Sleep
Volume8
Pages (from-to)107-20
Number of pages14
ISSN1179-1608
DOIs
Publication statusPublished - 2016

    Research areas

  • Journal Article, Review

ID: 49648922