Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools

Jesper Kelsen; Marianne Hald Clemmensen; Jens Christian H. Sørensen; Arne Møller; Jørgen Frøkiaer; Søren Nielsen; Jens Randel Nyengaard; Jens D Mikkelsen; Lars Christian B Rønn

doi:10.1186/2040-7378-2-8

Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools

Jesper Kelsen, Marianne Hald Clemmensen, Jens Christian H. Sørensen, Arne Møller, Jørgen Frøkiaer, Søren Nielsen, Jens Randel Nyengaard, Jens D Mikkelsen, Lars Christian B Rønn

7 Citations (Scopus)

Abstract

We are currently investigating microglial activation and neuronal precursor cell (NPC) proliferation after transient middle cerebral artery occlusion (tMCAo) in rats. This study aimed: (1) to investigate differences in hippocampal NPC proliferation in outbred male spontaneously hypertensive rats (SHRs) and Sprague-Dawley rats (SDs) one week after tMCAo; (2) to present the practical use of the optical fractionator and 2D nucleator in stereological brain tissue analyses; and (3) to report our experiences with an intraluminal tMCAo model where the occluding filament is advanced 22 mm beyond the carotid bifurcation and the common carotid artery is clamped during tMCAo.

Original language	English
Journal	Experimental & translational stroke medicine
Volume	2
Pages (from-to)	8
DOIs	https://doi.org/10.1186/2040-7378-2-8
Publication status	Published - 1 Jan 2010

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10.1186/2040-7378-2-8

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Kelsen, J., Clemmensen, M. H., Sørensen, J. C. H., Møller, A., Frøkiaer, J., Nielsen, S., Nyengaard, J. R., Mikkelsen, J. D., & Rønn, L. C. B. (2010). Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools. Experimental & translational stroke medicine, 2, 8. https://doi.org/10.1186/2040-7378-2-8

Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools. / Kelsen, Jesper; Clemmensen, Marianne Hald; Sørensen, Jens Christian H. et al.
In: Experimental & translational stroke medicine, Vol. 2, 01.01.2010, p. 8.

Research output: Contribution to journal › Journal article › Research › peer-review

Kelsen, J, Clemmensen, MH, Sørensen, JCH, Møller, A, Frøkiaer, J, Nielsen, S, Nyengaard, JR, Mikkelsen, JD & Rønn, LCB 2010, 'Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools', Experimental & translational stroke medicine, vol. 2, pp. 8. https://doi.org/10.1186/2040-7378-2-8

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abstract = "We are currently investigating microglial activation and neuronal precursor cell (NPC) proliferation after transient middle cerebral artery occlusion (tMCAo) in rats. This study aimed: (1) to investigate differences in hippocampal NPC proliferation in outbred male spontaneously hypertensive rats (SHRs) and Sprague-Dawley rats (SDs) one week after tMCAo; (2) to present the practical use of the optical fractionator and 2D nucleator in stereological brain tissue analyses; and (3) to report our experiences with an intraluminal tMCAo model where the occluding filament is advanced 22 mm beyond the carotid bifurcation and the common carotid artery is clamped during tMCAo.",

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AU - Kelsen, Jesper

AU - Clemmensen, Marianne Hald

AU - Sørensen, Jens Christian H.

AU - Møller, Arne

AU - Frøkiaer, Jørgen

AU - Nielsen, Søren

AU - Nyengaard, Jens Randel

AU - Mikkelsen, Jens D

AU - Rønn, Lars Christian B

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N2 - We are currently investigating microglial activation and neuronal precursor cell (NPC) proliferation after transient middle cerebral artery occlusion (tMCAo) in rats. This study aimed: (1) to investigate differences in hippocampal NPC proliferation in outbred male spontaneously hypertensive rats (SHRs) and Sprague-Dawley rats (SDs) one week after tMCAo; (2) to present the practical use of the optical fractionator and 2D nucleator in stereological brain tissue analyses; and (3) to report our experiences with an intraluminal tMCAo model where the occluding filament is advanced 22 mm beyond the carotid bifurcation and the common carotid artery is clamped during tMCAo.

AB - We are currently investigating microglial activation and neuronal precursor cell (NPC) proliferation after transient middle cerebral artery occlusion (tMCAo) in rats. This study aimed: (1) to investigate differences in hippocampal NPC proliferation in outbred male spontaneously hypertensive rats (SHRs) and Sprague-Dawley rats (SDs) one week after tMCAo; (2) to present the practical use of the optical fractionator and 2D nucleator in stereological brain tissue analyses; and (3) to report our experiences with an intraluminal tMCAo model where the occluding filament is advanced 22 mm beyond the carotid bifurcation and the common carotid artery is clamped during tMCAo.

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U2 - 10.1186/2040-7378-2-8

DO - 10.1186/2040-7378-2-8

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VL - 2

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JO - Experimental & translational stroke medicine

JF - Experimental & translational stroke medicine

ER -

Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools

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