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Neuromedin U does not act as a decretin in rats

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  • Rune Ehrenreich Kuhre
  • Charlotte Bayer Christiansen
  • Seyed Mojtaba Ghiasi
  • Maria Buur Nordskov Gabe
  • Patricia Almine Skat-Rørdam
  • Ida Marie Modvig
  • Thomas Mandrup-Poulsen
  • Reidar Albrechtsen
  • Mette Marie Rosenkilde
  • Bolette Hartmann
  • Nicolai Jacob Wewer Albrechtsen
  • Jens Juul Holst
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Studies on isolated pancreatic islets suggest that neuromedin U (NMU), a brain and gastrointestinal peptide, acts as a decretin hormone, inhibiting glucose-stimulated insulin secretion. We investigated whether this effect could be reproduced in vivo and in isolated perfused rat pancreas. Unlike the incretin hormone, glucagon-like peptide 1 (GLP-1), intravenous NMU administration had no effects on blood glucose and plasma insulin and glucagon in vivo. Moreover, NMU neither changed insulin, glucagon, or somatostatin secretion from isolated perfused rat pancreas, nor affected GLP-1-stimulated insulin and somatostatin secretion. For NMU to act as a decretin hormone, its secretion should increase following glucose ingestion; however, glucose did not affect NMU secretion from isolated perfused rat small intestine, which contained extractable NMU. Furthermore, the two NMU receptors were not detected in endocrine rat or human pancreas. We conclude that NMU does not act as a decretin hormone in rats.

Original languageEnglish
JournalCell Metabolism
Volume29
Issue number3
Pages (from-to)719-726
ISSN1550-4131
DOIs
Publication statusPublished - 5 Mar 2019

ID: 58198491