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Neurological diseases and risk of suicide attempt: a case-control study

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@article{7ad10a9fd96c4a8e8740c3aa8e21b48d,
title = "Neurological diseases and risk of suicide attempt: a case-control study",
abstract = "INTRODUCTION: Neurological diseases have a profound impact on quality of life. We investigated the risk of suicide attempt in ten neurological diseases.METHODS: Case-control study. Cases were identified from the Danish Poison Information Centre database in the period 2006-2013. The prevalence of ten neurological diagnoses was compared with the prevalence in a randomly sampled age- and gender-matched control group.RESULTS: We identified 8974 cases of suicidal attempt and 89,740 controls. We found an association between suicide attempt in nine of ten neurological diseases and disease groups, including stroke [odds ratio (OR) 3.1, 95% confidence interval (CI) (2.8-3.6)], Huntington's disease [OR 8.8, 95% CI (3.2-24.1)], amyotrophic lateral sclerosis [OR 5.0, 95% CI (1.7-14.6)], Parkinson's disease [OR 2.9, 95% CI (1.8-4.6)], Alzheimer's disease and other degenerative diseases [OR 4.8, 95% CI (3.1-7.5)], multiple sclerosis [OR 1.5, 95% CI (1.1-2.1)], epilepsy [OR 4.5, 95% CI (4.1-5.0)], hereditary and idiopathic neuropathy [OR 2.2, 95% CI (1.1-4.3)] and myasthenia gravis [OR 4.3, 95% CI (2.0-9.4)].CONCLUSION: Nine out of ten chronic neurological diseases were associated with an increased risk of suicide attempt. These data must be considered for clinicians treating this vulnerable group of patients.",
keywords = "Adult, Aged, Case-Control Studies, Chronic Disease, Comorbidity, Denmark, Female, Humans, Male, Middle Aged, Nervous System Diseases/epidemiology, Odds Ratio, Poisoning/epidemiology, Prevalence, Prospective Studies, Registries, Risk Factors, Suicide, Attempted",
author = "Astrid Eliasen and Dalhoff, {Kim Peder} and Henrik Horwitz",
year = "2018",
month = jun,
doi = "10.1007/s00415-018-8837-4",
language = "English",
volume = "265",
pages = "1303--1309",
journal = "Journal of Neurology",
issn = "0340-5354",
publisher = "Dr. Dietrich/Steinkopff Verlag",
number = "6",

}

RIS

TY - JOUR

T1 - Neurological diseases and risk of suicide attempt

T2 - a case-control study

AU - Eliasen, Astrid

AU - Dalhoff, Kim Peder

AU - Horwitz, Henrik

PY - 2018/6

Y1 - 2018/6

N2 - INTRODUCTION: Neurological diseases have a profound impact on quality of life. We investigated the risk of suicide attempt in ten neurological diseases.METHODS: Case-control study. Cases were identified from the Danish Poison Information Centre database in the period 2006-2013. The prevalence of ten neurological diagnoses was compared with the prevalence in a randomly sampled age- and gender-matched control group.RESULTS: We identified 8974 cases of suicidal attempt and 89,740 controls. We found an association between suicide attempt in nine of ten neurological diseases and disease groups, including stroke [odds ratio (OR) 3.1, 95% confidence interval (CI) (2.8-3.6)], Huntington's disease [OR 8.8, 95% CI (3.2-24.1)], amyotrophic lateral sclerosis [OR 5.0, 95% CI (1.7-14.6)], Parkinson's disease [OR 2.9, 95% CI (1.8-4.6)], Alzheimer's disease and other degenerative diseases [OR 4.8, 95% CI (3.1-7.5)], multiple sclerosis [OR 1.5, 95% CI (1.1-2.1)], epilepsy [OR 4.5, 95% CI (4.1-5.0)], hereditary and idiopathic neuropathy [OR 2.2, 95% CI (1.1-4.3)] and myasthenia gravis [OR 4.3, 95% CI (2.0-9.4)].CONCLUSION: Nine out of ten chronic neurological diseases were associated with an increased risk of suicide attempt. These data must be considered for clinicians treating this vulnerable group of patients.

AB - INTRODUCTION: Neurological diseases have a profound impact on quality of life. We investigated the risk of suicide attempt in ten neurological diseases.METHODS: Case-control study. Cases were identified from the Danish Poison Information Centre database in the period 2006-2013. The prevalence of ten neurological diagnoses was compared with the prevalence in a randomly sampled age- and gender-matched control group.RESULTS: We identified 8974 cases of suicidal attempt and 89,740 controls. We found an association between suicide attempt in nine of ten neurological diseases and disease groups, including stroke [odds ratio (OR) 3.1, 95% confidence interval (CI) (2.8-3.6)], Huntington's disease [OR 8.8, 95% CI (3.2-24.1)], amyotrophic lateral sclerosis [OR 5.0, 95% CI (1.7-14.6)], Parkinson's disease [OR 2.9, 95% CI (1.8-4.6)], Alzheimer's disease and other degenerative diseases [OR 4.8, 95% CI (3.1-7.5)], multiple sclerosis [OR 1.5, 95% CI (1.1-2.1)], epilepsy [OR 4.5, 95% CI (4.1-5.0)], hereditary and idiopathic neuropathy [OR 2.2, 95% CI (1.1-4.3)] and myasthenia gravis [OR 4.3, 95% CI (2.0-9.4)].CONCLUSION: Nine out of ten chronic neurological diseases were associated with an increased risk of suicide attempt. These data must be considered for clinicians treating this vulnerable group of patients.

KW - Adult

KW - Aged

KW - Case-Control Studies

KW - Chronic Disease

KW - Comorbidity

KW - Denmark

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Nervous System Diseases/epidemiology

KW - Odds Ratio

KW - Poisoning/epidemiology

KW - Prevalence

KW - Prospective Studies

KW - Registries

KW - Risk Factors

KW - Suicide, Attempted

U2 - 10.1007/s00415-018-8837-4

DO - 10.1007/s00415-018-8837-4

M3 - Journal article

C2 - 29564603

VL - 265

SP - 1303

EP - 1309

JO - Journal of Neurology

JF - Journal of Neurology

SN - 0340-5354

IS - 6

ER -

ID: 55741588