Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Neurologic disorders in long-term survivors of neuroblastoma - a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) research program

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Norsker, FN, Rechnitzer, C, Andersen, EW, Linnet, KM, Kenborg, L, Holmqvist, AS, Tryggvadottir, L, Madanat-Harjuoja, L-M, Øra, I, Thorarinsdottir, HK, Vettenranta, K, Bautz, A, Schrøder, H, Hasle, H & Winther, JF 2020, 'Neurologic disorders in long-term survivors of neuroblastoma - a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) research program' Acta oncologica , vol. 59, no. 2, pp. 134-140. https://doi.org/10.1080/0284186X.2019.1672892

APA

CBE

Norsker FN, Rechnitzer C, Andersen EW, Linnet KM, Kenborg L, Holmqvist AS, Tryggvadottir L, Madanat-Harjuoja L-M, Øra I, Thorarinsdottir HK, Vettenranta K, Bautz A, Schrøder H, Hasle H, Winther JF. 2020. Neurologic disorders in long-term survivors of neuroblastoma - a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) research program. Acta oncologica . 59(2):134-140. https://doi.org/10.1080/0284186X.2019.1672892

MLA

Vancouver

Author

Norsker, Filippa Nyboe ; Rechnitzer, Catherine ; Andersen, Elisabeth Wreford ; Linnet, Karen Markussen ; Kenborg, Line ; Holmqvist, Anna Sällfors ; Tryggvadottir, Laufey ; Madanat-Harjuoja, Laura-Maria ; Øra, Ingrid ; Thorarinsdottir, Halldora K ; Vettenranta, Kim ; Bautz, Andrea ; Schrøder, Henrik ; Hasle, Henrik ; Winther, Jeanette Falck. / Neurologic disorders in long-term survivors of neuroblastoma - a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) research program. In: Acta oncologica . 2020 ; Vol. 59, No. 2. pp. 134-140.

Bibtex

@article{0765fc7b0dd4494fbb4b1ec62353fa08,
title = "Neurologic disorders in long-term survivors of neuroblastoma - a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) research program",
abstract = "Background: Neuroblastoma is the commonest extracranial solid tumor of childhood, yet rare, and with poor survival before 1990, especially for high-risk disease; thus, information on late effects is sparse. With great advances in cancer treatment, survival has reached 80{\%} in the Nordic countries. The aim of the study was to investigate the risk of developing neurologic disorders after neuroblastoma. Material and methods: Through population-based cancer registries of four Nordic countries we identified 654 5-year survivors of neuroblastoma (diagnosed 1959-2008) and 133,668 matched population comparisons. We grouped neurologic diagnoses from national hospital registries into 11 main diagnostic categories and 56 disease-specific sub-categories and calculated relative risks (RRs), absolute excess risks (AERs), cumulative incidence and mean cumulative count (MCC). Information on cancer treatment was available for 49{\%} of survivors. Results: A hospital contact for a neurologic disorder was observed in 181 survivors 5 years or more from cancer diagnosis with 59 expected, yielding a RR of 3.1 (95{\%} CI 2.7-3.6) and an AER of 16 per 1,000 person-years (95{\%} CI 12-19). The most frequent disorders included epilepsy, paralytic syndromes, diseases of the eyes and ears and hearing loss. The cumulative incidence of any neurologic disorder was 31{\%} in survivors 20 years after cancer diagnosis with a MCC of 0.5 unique diagnoses. All risks were highest in survivors of high-risk neuroblastoma. Conclusion: Neuroblastoma survivors represent a population with a high risk of developing neurologic disorders. Our results should contribute to improving health care planning and underscores the need for systematic follow-up care of this vulnerable group of survivors.",
author = "Norsker, {Filippa Nyboe} and Catherine Rechnitzer and Andersen, {Elisabeth Wreford} and Linnet, {Karen Markussen} and Line Kenborg and Holmqvist, {Anna S{\"a}llfors} and Laufey Tryggvadottir and Laura-Maria Madanat-Harjuoja and Ingrid {\O}ra and Thorarinsdottir, {Halldora K} and Kim Vettenranta and Andrea Bautz and Henrik Schr{\o}der and Henrik Hasle and Winther, {Jeanette Falck}",
year = "2020",
month = "2",
doi = "10.1080/0284186X.2019.1672892",
language = "English",
volume = "59",
pages = "134--140",
journal = "Acta Oncologica",
issn = "0284-186X",
publisher = "Informa Healthcare",
number = "2",

}

RIS

TY - JOUR

T1 - Neurologic disorders in long-term survivors of neuroblastoma - a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) research program

AU - Norsker, Filippa Nyboe

AU - Rechnitzer, Catherine

AU - Andersen, Elisabeth Wreford

AU - Linnet, Karen Markussen

AU - Kenborg, Line

AU - Holmqvist, Anna Sällfors

AU - Tryggvadottir, Laufey

AU - Madanat-Harjuoja, Laura-Maria

AU - Øra, Ingrid

AU - Thorarinsdottir, Halldora K

AU - Vettenranta, Kim

AU - Bautz, Andrea

AU - Schrøder, Henrik

AU - Hasle, Henrik

AU - Winther, Jeanette Falck

PY - 2020/2

Y1 - 2020/2

N2 - Background: Neuroblastoma is the commonest extracranial solid tumor of childhood, yet rare, and with poor survival before 1990, especially for high-risk disease; thus, information on late effects is sparse. With great advances in cancer treatment, survival has reached 80% in the Nordic countries. The aim of the study was to investigate the risk of developing neurologic disorders after neuroblastoma. Material and methods: Through population-based cancer registries of four Nordic countries we identified 654 5-year survivors of neuroblastoma (diagnosed 1959-2008) and 133,668 matched population comparisons. We grouped neurologic diagnoses from national hospital registries into 11 main diagnostic categories and 56 disease-specific sub-categories and calculated relative risks (RRs), absolute excess risks (AERs), cumulative incidence and mean cumulative count (MCC). Information on cancer treatment was available for 49% of survivors. Results: A hospital contact for a neurologic disorder was observed in 181 survivors 5 years or more from cancer diagnosis with 59 expected, yielding a RR of 3.1 (95% CI 2.7-3.6) and an AER of 16 per 1,000 person-years (95% CI 12-19). The most frequent disorders included epilepsy, paralytic syndromes, diseases of the eyes and ears and hearing loss. The cumulative incidence of any neurologic disorder was 31% in survivors 20 years after cancer diagnosis with a MCC of 0.5 unique diagnoses. All risks were highest in survivors of high-risk neuroblastoma. Conclusion: Neuroblastoma survivors represent a population with a high risk of developing neurologic disorders. Our results should contribute to improving health care planning and underscores the need for systematic follow-up care of this vulnerable group of survivors.

AB - Background: Neuroblastoma is the commonest extracranial solid tumor of childhood, yet rare, and with poor survival before 1990, especially for high-risk disease; thus, information on late effects is sparse. With great advances in cancer treatment, survival has reached 80% in the Nordic countries. The aim of the study was to investigate the risk of developing neurologic disorders after neuroblastoma. Material and methods: Through population-based cancer registries of four Nordic countries we identified 654 5-year survivors of neuroblastoma (diagnosed 1959-2008) and 133,668 matched population comparisons. We grouped neurologic diagnoses from national hospital registries into 11 main diagnostic categories and 56 disease-specific sub-categories and calculated relative risks (RRs), absolute excess risks (AERs), cumulative incidence and mean cumulative count (MCC). Information on cancer treatment was available for 49% of survivors. Results: A hospital contact for a neurologic disorder was observed in 181 survivors 5 years or more from cancer diagnosis with 59 expected, yielding a RR of 3.1 (95% CI 2.7-3.6) and an AER of 16 per 1,000 person-years (95% CI 12-19). The most frequent disorders included epilepsy, paralytic syndromes, diseases of the eyes and ears and hearing loss. The cumulative incidence of any neurologic disorder was 31% in survivors 20 years after cancer diagnosis with a MCC of 0.5 unique diagnoses. All risks were highest in survivors of high-risk neuroblastoma. Conclusion: Neuroblastoma survivors represent a population with a high risk of developing neurologic disorders. Our results should contribute to improving health care planning and underscores the need for systematic follow-up care of this vulnerable group of survivors.

U2 - 10.1080/0284186X.2019.1672892

DO - 10.1080/0284186X.2019.1672892

M3 - Journal article

VL - 59

SP - 134

EP - 140

JO - Acta Oncologica

JF - Acta Oncologica

SN - 0284-186X

IS - 2

ER -

ID: 59232318