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Neuroinflammatory markers associate with cognitive decline after major surgery: findings of an explorative study

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Harvard

Danielson, M, Wiklund, A, Granath, F, Blennow, K, Mkrtchian, S, Nellgård, B, Oras, J, Jonsson Fagerlund, M, Granström, A, Schening, A, Rasmussen, LS, Erlandsson Harris, H, Zetterberg, H, Ricksten, S-E & Eriksson, LI 2020, 'Neuroinflammatory markers associate with cognitive decline after major surgery: findings of an explorative study' Annals of Neurology, vol. 87, no. 3, pp. 370-382. https://doi.org/10.1002/ana.25678

APA

Danielson, M., Wiklund, A., Granath, F., Blennow, K., Mkrtchian, S., Nellgård, B., ... Eriksson, L. I. (2020). Neuroinflammatory markers associate with cognitive decline after major surgery: findings of an explorative study. Annals of Neurology, 87(3), 370-382. https://doi.org/10.1002/ana.25678

CBE

Danielson M, Wiklund A, Granath F, Blennow K, Mkrtchian S, Nellgård B, Oras J, Jonsson Fagerlund M, Granström A, Schening A, Rasmussen LS, Erlandsson Harris H, Zetterberg H, Ricksten S-E, Eriksson LI. 2020. Neuroinflammatory markers associate with cognitive decline after major surgery: findings of an explorative study. Annals of Neurology. 87(3):370-382. https://doi.org/10.1002/ana.25678

MLA

Vancouver

Author

Danielson, Mattias ; Wiklund, Andreas ; Granath, Fredrik ; Blennow, Kaj ; Mkrtchian, Souren ; Nellgård, Bengt ; Oras, Jonatan ; Jonsson Fagerlund, Malin ; Granström, Anna ; Schening, Anna ; Rasmussen, Lars S ; Erlandsson Harris, Helena ; Zetterberg, Henrik ; Ricksten, Sven-Erik ; Eriksson, Lars I. / Neuroinflammatory markers associate with cognitive decline after major surgery : findings of an explorative study. In: Annals of Neurology. 2020 ; Vol. 87, No. 3. pp. 370-382.

Bibtex

@article{c9532db4a7d749d7a9c4526f779daf5b,
title = "Neuroinflammatory markers associate with cognitive decline after major surgery: findings of an explorative study",
abstract = "Objective: Long-term cognitive decline is an adverse outcome after major surgery associated with increased risk for mortality and morbidity. We studied the cerebrospinal fluid (CSF) and serum biochemical inflammatory response to a standardized orthopedic surgical procedure and the possible association with long-term changes in cognitive function. We hypothesized that the CSF inflammatory response pattern after surgery would differ in patients having long-term cognitive decline defined as a composite cognitive z score of ≥1.0 compared to patients without long-term cognitive decline at 3 months postsurgery. Methods: Serum and CSF biomarkers of inflammation and blood–brain barrier (BBB) integrity were measured preoperatively and up to 48 hours postoperatively, and cognitive function was assessed preoperatively and at 2 to 5 days and 3 months postoperatively. Results: Surgery was associated with a pronounced increase in inflammatory biomarkers in both CSF and blood throughout the 48-hour study period. A principal component (PC) analysis was performed on 52 inflammatory biomarkers. The 2 first PC (PC1 and PC2) construct outcome variables on CSF biomarkers were significantly associated with long-term cognitive decline at 3 months, but none of the PC construct serum variables showed a significant association with long-term cognitive decline at 3 months. Patients both with and patients without long-term cognitive decline showed early transient increases of the astroglial biomarkers S-100B and glial fibrillary acidic protein in CSF, and in BBB permeability (CSF/serum albumin ratio). Interpretation: Surgery rapidly triggers a temporal neuroinflammatory response closely associated with long-term cognitive outcome postsurgery. The findings of this explorative study require validation in a larger surgical patient cohort. Ann Neurol 2020;87:370–382.",
author = "Mattias Danielson and Andreas Wiklund and Fredrik Granath and Kaj Blennow and Souren Mkrtchian and Bengt Nellg{\aa}rd and Jonatan Oras and {Jonsson Fagerlund}, Malin and Anna Granstr{\"o}m and Anna Schening and Rasmussen, {Lars S} and {Erlandsson Harris}, Helena and Henrik Zetterberg and Sven-Erik Ricksten and Eriksson, {Lars I}",
note = "{\circledC} 2020 The Authors. Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association.",
year = "2020",
month = "3",
doi = "10.1002/ana.25678",
language = "English",
volume = "87",
pages = "370--382",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Neuroinflammatory markers associate with cognitive decline after major surgery

T2 - findings of an explorative study

AU - Danielson, Mattias

AU - Wiklund, Andreas

AU - Granath, Fredrik

AU - Blennow, Kaj

AU - Mkrtchian, Souren

AU - Nellgård, Bengt

AU - Oras, Jonatan

AU - Jonsson Fagerlund, Malin

AU - Granström, Anna

AU - Schening, Anna

AU - Rasmussen, Lars S

AU - Erlandsson Harris, Helena

AU - Zetterberg, Henrik

AU - Ricksten, Sven-Erik

AU - Eriksson, Lars I

N1 - © 2020 The Authors. Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association.

PY - 2020/3

Y1 - 2020/3

N2 - Objective: Long-term cognitive decline is an adverse outcome after major surgery associated with increased risk for mortality and morbidity. We studied the cerebrospinal fluid (CSF) and serum biochemical inflammatory response to a standardized orthopedic surgical procedure and the possible association with long-term changes in cognitive function. We hypothesized that the CSF inflammatory response pattern after surgery would differ in patients having long-term cognitive decline defined as a composite cognitive z score of ≥1.0 compared to patients without long-term cognitive decline at 3 months postsurgery. Methods: Serum and CSF biomarkers of inflammation and blood–brain barrier (BBB) integrity were measured preoperatively and up to 48 hours postoperatively, and cognitive function was assessed preoperatively and at 2 to 5 days and 3 months postoperatively. Results: Surgery was associated with a pronounced increase in inflammatory biomarkers in both CSF and blood throughout the 48-hour study period. A principal component (PC) analysis was performed on 52 inflammatory biomarkers. The 2 first PC (PC1 and PC2) construct outcome variables on CSF biomarkers were significantly associated with long-term cognitive decline at 3 months, but none of the PC construct serum variables showed a significant association with long-term cognitive decline at 3 months. Patients both with and patients without long-term cognitive decline showed early transient increases of the astroglial biomarkers S-100B and glial fibrillary acidic protein in CSF, and in BBB permeability (CSF/serum albumin ratio). Interpretation: Surgery rapidly triggers a temporal neuroinflammatory response closely associated with long-term cognitive outcome postsurgery. The findings of this explorative study require validation in a larger surgical patient cohort. Ann Neurol 2020;87:370–382.

AB - Objective: Long-term cognitive decline is an adverse outcome after major surgery associated with increased risk for mortality and morbidity. We studied the cerebrospinal fluid (CSF) and serum biochemical inflammatory response to a standardized orthopedic surgical procedure and the possible association with long-term changes in cognitive function. We hypothesized that the CSF inflammatory response pattern after surgery would differ in patients having long-term cognitive decline defined as a composite cognitive z score of ≥1.0 compared to patients without long-term cognitive decline at 3 months postsurgery. Methods: Serum and CSF biomarkers of inflammation and blood–brain barrier (BBB) integrity were measured preoperatively and up to 48 hours postoperatively, and cognitive function was assessed preoperatively and at 2 to 5 days and 3 months postoperatively. Results: Surgery was associated with a pronounced increase in inflammatory biomarkers in both CSF and blood throughout the 48-hour study period. A principal component (PC) analysis was performed on 52 inflammatory biomarkers. The 2 first PC (PC1 and PC2) construct outcome variables on CSF biomarkers were significantly associated with long-term cognitive decline at 3 months, but none of the PC construct serum variables showed a significant association with long-term cognitive decline at 3 months. Patients both with and patients without long-term cognitive decline showed early transient increases of the astroglial biomarkers S-100B and glial fibrillary acidic protein in CSF, and in BBB permeability (CSF/serum albumin ratio). Interpretation: Surgery rapidly triggers a temporal neuroinflammatory response closely associated with long-term cognitive outcome postsurgery. The findings of this explorative study require validation in a larger surgical patient cohort. Ann Neurol 2020;87:370–382.

U2 - 10.1002/ana.25678

DO - 10.1002/ana.25678

M3 - Journal article

VL - 87

SP - 370

EP - 382

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 3

ER -

ID: 58974321