Neurofilament protein levels in CSF are increased in dementia

L E Rosengren, J E Karlsson, M Sjögren, K Blennow, A Wallin

138 Citations (Scopus)

Abstract

The neurofilament is the major cytoskeletal structure of myelinated axons. In this study, CSF levels of the light subunit of the neurofilament protein (NFL) were increased in patients with vascular dementia (VAD), AD, and frontotemporal dementia (FTD) compared with neurologically healthy individuals. Because NFL is localized mainly in myelinated axons, these results suggest that the degeneration of white matter in these disorders causes the increased CSF NFL levels.

Original languageEnglish
JournalNeurology
Volume52
Issue number5
Pages (from-to)1090-3
Number of pages4
ISSN0028-3878
Publication statusPublished - 23 Mar 1999
Externally publishedYes

Keywords

  • Aged
  • Alzheimer Disease
  • Dementia
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neurofilament Proteins
  • Journal Article
  • Research Support, Non-U.S. Gov't

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