Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Neurodevelopmental outcomes in children with isolated congenital diaphragmatic hernia: a systematic review and meta-analysis

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. Prenatal prediction of fetal Rh C, c and E status by amplification of maternal cfDNA and deep sequencing

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Trisomy 8 mosaicism in the placenta: A Danish cohort study of 37 cases and a literature review

    Research output: Contribution to journalReviewResearchpeer-review

  3. Performance of first trimester screening for Trisomy 21 in twin pregnancies

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Lennart Van der Veeken
  • Simen Vergote
  • Yada Kunpalin
  • Karl Kristensen
  • Jan Deprest
  • Matteo Bruschettini
View graph of relations

BACKGROUND: Congenital diaphragmatic hernia (CDH) reportedly has neurologic consequences in childhood however little is known about the impact in isolated CDH.

AIMS: Herein we aimed to describe the risk of neurodevelopmental complications in children born with isolated CDH.

MATERIALS & METHODS: We systematically reviewed literature for reports on the neurological outcome of infants born with isolated CDH. The primary outcome was neurodevelopmental delay. Secondary outcomes included, motor skills, intelligence, vision, hearing, language and behavior abnormalities.

RESULTS: Thirteen out of 87 (15%) studies reported on isolated CDH, including 2624 out of 24,146 children. Neurodevelopmental delay was investigated in four studies and found to be present in 16% (3-34%) of children. This was mainly attributed to motor problems in 13% (2-30%), whereas cognitive dysfunction only in 5% (0-20%) and hearing in 3% (1-7%). One study assessed the effect of fetal surgery. When both isolated and non-isolated children were included, these numbers were higher.

DISCUSSION: This systematic review demonstrates that only a minority of studies focused on isolated CDH, with neurodevelopmental delay present in 16% of children born with CDH.

CONCLUSION: To accurately counsel patients, more research should focus on isolated CDH cases and examine children that underwent fetal surgery.

Original languageEnglish
Article number5916
JournalPrenatal Diagnosis
Volume42
Issue number3
Pages (from-to)318-329
Number of pages12
ISSN0197-3851
DOIs
Publication statusPublished - Mar 2022

ID: 61989294