Neurochemistry and cognition across age: Examining the link between working memory and neuronal and glial markers measured with 1H-MRS at 7T

Anouk Marsman; Anna Lind Hansen; Esben Thade Petersen; Hartwig R. Siebner; Carl-Johan Boraxbekk

Neurochemistry and cognition across age: Examining the link between working memory and neuronal and glial markers measured with 1H-MRS at 7T

Anouk Marsman, Anna Lind Hansen, Esben Thade Petersen, Hartwig R. Siebner, Carl-Johan Boraxbekk

Abstract

Ageing has been associated with widespread neurochemical changes and cognitive decline. The increased sensitivity and resolution of 1H-MRS at 7T could shed new light on the potential relationship between neurochemistry and cognition during ageing. Our data show that primarily levels of glial metabolic markers, and not neuronal markers, differed between younger, middle-aged and older normal individuals and were correlated with visuo-spatial working memory performance across these age groups. This suggests that glial markers may be more affected by ageing than neuronal markers and that there is a potential association between glial markers and visuo-spatial working memory performance during ageing.

Original language	English
Title of host publication	Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition
Number of pages	1
Publisher	The International Society for Magnetic Resonance in Medicine
Publication date	2020
Pages	1-1
Article number	1854
Publication status	Published - 2020
Event	ISMRM & SMRT Virtual Conference & Exhibition 2020 - Virtual conference Duration: 8 Aug 2020 → 14 Aug 2020 https://www.ismrm.org/20m/

Conference

Conference	ISMRM & SMRT Virtual Conference & Exhibition 2020
Location	Virtual conference
Period	08/08/2020 → 14/08/2020
Internet address	https://www.ismrm.org/20m/

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Marsman, A., Hansen, A. L., Petersen, E. T., Siebner, H. R., & Boraxbekk, C-J. (2020). Neurochemistry and cognition across age: Examining the link between working memory and neuronal and glial markers measured with 1H-MRS at 7T. In Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition (pp. 1-1). [1854] The International Society for Magnetic Resonance in Medicine. https://archive.ismrm.org/2020/1854.html

Neurochemistry and cognition across age: Examining the link between working memory and neuronal and glial markers measured with 1H-MRS at 7T. / Marsman, Anouk; Hansen, Anna Lind; Petersen, Esben Thade et al.

Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition. The International Society for Magnetic Resonance in Medicine, 2020. p. 1-1 1854.

Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research › peer-review

Marsman, A, Hansen, AL, Petersen, ET , Siebner, HR & Boraxbekk, C-J 2020, Neurochemistry and cognition across age: Examining the link between working memory and neuronal and glial markers measured with 1H-MRS at 7T. in Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition., 1854, The International Society for Magnetic Resonance in Medicine, pp. 1-1, ISMRM & SMRT Virtual Conference & Exhibition 2020, 08/08/2020. <https://archive.ismrm.org/2020/1854.html>

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abstract = "Ageing has been associated with widespread neurochemical changes and cognitive decline. The increased sensitivity and resolution of 1H-MRS at 7T could shed new light on the potential relationship between neurochemistry and cognition during ageing. Our data show that primarily levels of glial metabolic markers, and not neuronal markers, differed between younger, middle-aged and older normal individuals and were correlated with visuo-spatial working memory performance across these age groups. This suggests that glial markers may be more affected by ageing than neuronal markers and that there is a potential association between glial markers and visuo-spatial working memory performance during ageing.",

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T1 - Neurochemistry and cognition across age: Examining the link between working memory and neuronal and glial markers measured with 1H-MRS at 7T

AU - Marsman, Anouk

AU - Hansen, Anna Lind

AU - Petersen, Esben Thade

AU - Siebner, Hartwig R.

AU - Boraxbekk, Carl-Johan

PY - 2020

Y1 - 2020

N2 - Ageing has been associated with widespread neurochemical changes and cognitive decline. The increased sensitivity and resolution of 1H-MRS at 7T could shed new light on the potential relationship between neurochemistry and cognition during ageing. Our data show that primarily levels of glial metabolic markers, and not neuronal markers, differed between younger, middle-aged and older normal individuals and were correlated with visuo-spatial working memory performance across these age groups. This suggests that glial markers may be more affected by ageing than neuronal markers and that there is a potential association between glial markers and visuo-spatial working memory performance during ageing.

AB - Ageing has been associated with widespread neurochemical changes and cognitive decline. The increased sensitivity and resolution of 1H-MRS at 7T could shed new light on the potential relationship between neurochemistry and cognition during ageing. Our data show that primarily levels of glial metabolic markers, and not neuronal markers, differed between younger, middle-aged and older normal individuals and were correlated with visuo-spatial working memory performance across these age groups. This suggests that glial markers may be more affected by ageing than neuronal markers and that there is a potential association between glial markers and visuo-spatial working memory performance during ageing.

M3 - Conference abstract in proceedings

SP - 1

EP - 1

BT - Proceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition

PB - The International Society for Magnetic Resonance in Medicine

T2 - ISMRM & SMRT Virtual Conference & Exhibition 2020

Y2 - 8 August 2020 through 14 August 2020

ER -

Neurochemistry and cognition across age: Examining the link between working memory and neuronal and glial markers measured with 1H-MRS at 7T

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