Neonatal stimulation of the thyroid gland with iodine or suppression during adolescence with triiodothyronine changes the prevalence of autoimmune thyroiditis in BB rats

M-L Hartoft-Nielsen; A K Rasmussen; A Kaas; U Feldt-Rasmussen; K Buschard

doi:10.1530/eje.0.1510375

Neonatal stimulation of the thyroid gland with iodine or suppression during adolescence with triiodothyronine changes the prevalence of autoimmune thyroiditis in BB rats

M-L Hartoft-Nielsen, A K Rasmussen, A Kaas, U Feldt-Rasmussen, K Buschard

5 Citations (Scopus)

Abstract

OBJECTIVE: Changes in the functional state of beta cells by neonatal stimulation or adolescent suppression have reduced the incidence of type 1 diabetes mellitus in animal models. The aim of this study was to evaluate the effect of manipulation of the activity of the thyroid gland by neonatal stimulation or by adolescent suppression on the prevalence of spontaneous autoimmune thyroiditis (AIT) in rats.

METHODS: Bio-Breeding/Worcester (BB) rats were treated neonatally with sodium iodine (NaI) or thyroid stimulating hormone (TSH), or during adolescence by triiodothyronine (T(3)), and the lymphocytic infiltration in the thyroid gland was evaluated.

RESULTS: Neonatal treatment with NaI decreased the prevalence of AIT to 32+/-9% compared with 66+/-5% in the controls (P<0.002), mainly caused by a reduction among the female rats (13+/-9% vs 52+/-8%, P<0.006). TSH had no effect. Post neonatal suppression of the thyroid gland by T(3) had a biphasic response. Early in adolescence the overall prevalence was 14+/-7% compared with 66+/-5% in the controls (P<10(-5)); for female rats AIT was prevented (0+/-0%) compared with 52+/-8% in the controls (P<0.0003) and in male rats the values were 29+/-13% compared with 80+/-6% in the controls (P<0.001). Treatment with T(3) later in adolescence increased the overall prevalence to 81+/-7% compared with 66+/-5% in the controls (not significant). For female rats the prevalence increased to 78+/-9% compared with 52+/-8% in the controls (P=0.04). The degree of thyroiditis among the affected animals was similar in all groups.

CONCLUSION: Neonatal stimulation of the thyroid gland by iodine or early adolescent suppression by T(3) reduced the prevalence of AIT whereas T(3) given later increased the prevalence of thyroiditis in rats. Thyroid activity at various ages seems to be of importance for the development of autoimmune thyroiditis.

Original language	English
Journal	European Journal of Endocrinology
Volume	151
Issue number	3
Pages (from-to)	375-82
Number of pages	8
ISSN	0804-4643
DOIs	https://doi.org/10.1530/eje.0.1510375
Publication status	Published - Sept 2004
Externally published	Yes

Keywords

Age Factors
Animals
Animals, Newborn
Body Weight
Female
Male
Prevalence
Rats
Rats, Inbred Strains
Sodium Iodide/pharmacology
Thyroid Gland/drug effects
Thyroiditis, Autoimmune/epidemiology
Thyrotropin/blood
Thyroxine/blood
Triiodothyronine/pharmacology

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10.1530/eje.0.1510375

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Neonatal stimulation of the thyroid gland with iodine or suppression during adolescence with triiodothyronine changes the prevalence of autoimmune thyroiditis in BB rats. / Hartoft-Nielsen, M-L; Rasmussen, A K; Kaas, A et al.
In: European Journal of Endocrinology, Vol. 151, No. 3, 09.2004, p. 375-82.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Neonatal stimulation of the thyroid gland with iodine or suppression during adolescence with triiodothyronine changes the prevalence of autoimmune thyroiditis in BB rats",

abstract = "OBJECTIVE: Changes in the functional state of beta cells by neonatal stimulation or adolescent suppression have reduced the incidence of type 1 diabetes mellitus in animal models. The aim of this study was to evaluate the effect of manipulation of the activity of the thyroid gland by neonatal stimulation or by adolescent suppression on the prevalence of spontaneous autoimmune thyroiditis (AIT) in rats.METHODS: Bio-Breeding/Worcester (BB) rats were treated neonatally with sodium iodine (NaI) or thyroid stimulating hormone (TSH), or during adolescence by triiodothyronine (T(3)), and the lymphocytic infiltration in the thyroid gland was evaluated.RESULTS: Neonatal treatment with NaI decreased the prevalence of AIT to 32+/-9\% compared with 66+/-5\% in the controls (P<0.002), mainly caused by a reduction among the female rats (13+/-9\% vs 52+/-8\%, P<0.006). TSH had no effect. Post neonatal suppression of the thyroid gland by T(3) had a biphasic response. Early in adolescence the overall prevalence was 14+/-7\% compared with 66+/-5\% in the controls (P<10(-5)); for female rats AIT was prevented (0+/-0\%) compared with 52+/-8\% in the controls (P<0.0003) and in male rats the values were 29+/-13\% compared with 80+/-6\% in the controls (P<0.001). Treatment with T(3) later in adolescence increased the overall prevalence to 81+/-7\% compared with 66+/-5\% in the controls (not significant). For female rats the prevalence increased to 78+/-9\% compared with 52+/-8\% in the controls (P=0.04). The degree of thyroiditis among the affected animals was similar in all groups.CONCLUSION: Neonatal stimulation of the thyroid gland by iodine or early adolescent suppression by T(3) reduced the prevalence of AIT whereas T(3) given later increased the prevalence of thyroiditis in rats. Thyroid activity at various ages seems to be of importance for the development of autoimmune thyroiditis.",

keywords = "Age Factors, Animals, Animals, Newborn, Body Weight, Female, Male, Prevalence, Rats, Rats, Inbred Strains, Sodium Iodide/pharmacology, Thyroid Gland/drug effects, Thyroiditis, Autoimmune/epidemiology, Thyrotropin/blood, Thyroxine/blood, Triiodothyronine/pharmacology",

author = "M-L Hartoft-Nielsen and Rasmussen, \{A K\} and A Kaas and U Feldt-Rasmussen and K Buschard",

year = "2004",

month = sep,

doi = "10.1530/eje.0.1510375",

language = "English",

volume = "151",

pages = "375--82",

journal = "European Journal of Endocrinology",

issn = "0804-4643",

publisher = "BioScientifica Ltd.",

number = "3",

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TY - JOUR

T1 - Neonatal stimulation of the thyroid gland with iodine or suppression during adolescence with triiodothyronine changes the prevalence of autoimmune thyroiditis in BB rats

AU - Hartoft-Nielsen, M-L

AU - Rasmussen, A K

AU - Kaas, A

AU - Feldt-Rasmussen, U

AU - Buschard, K

PY - 2004/9

Y1 - 2004/9

N2 - OBJECTIVE: Changes in the functional state of beta cells by neonatal stimulation or adolescent suppression have reduced the incidence of type 1 diabetes mellitus in animal models. The aim of this study was to evaluate the effect of manipulation of the activity of the thyroid gland by neonatal stimulation or by adolescent suppression on the prevalence of spontaneous autoimmune thyroiditis (AIT) in rats.METHODS: Bio-Breeding/Worcester (BB) rats were treated neonatally with sodium iodine (NaI) or thyroid stimulating hormone (TSH), or during adolescence by triiodothyronine (T(3)), and the lymphocytic infiltration in the thyroid gland was evaluated.RESULTS: Neonatal treatment with NaI decreased the prevalence of AIT to 32+/-9% compared with 66+/-5% in the controls (P<0.002), mainly caused by a reduction among the female rats (13+/-9% vs 52+/-8%, P<0.006). TSH had no effect. Post neonatal suppression of the thyroid gland by T(3) had a biphasic response. Early in adolescence the overall prevalence was 14+/-7% compared with 66+/-5% in the controls (P<10(-5)); for female rats AIT was prevented (0+/-0%) compared with 52+/-8% in the controls (P<0.0003) and in male rats the values were 29+/-13% compared with 80+/-6% in the controls (P<0.001). Treatment with T(3) later in adolescence increased the overall prevalence to 81+/-7% compared with 66+/-5% in the controls (not significant). For female rats the prevalence increased to 78+/-9% compared with 52+/-8% in the controls (P=0.04). The degree of thyroiditis among the affected animals was similar in all groups.CONCLUSION: Neonatal stimulation of the thyroid gland by iodine or early adolescent suppression by T(3) reduced the prevalence of AIT whereas T(3) given later increased the prevalence of thyroiditis in rats. Thyroid activity at various ages seems to be of importance for the development of autoimmune thyroiditis.

AB - OBJECTIVE: Changes in the functional state of beta cells by neonatal stimulation or adolescent suppression have reduced the incidence of type 1 diabetes mellitus in animal models. The aim of this study was to evaluate the effect of manipulation of the activity of the thyroid gland by neonatal stimulation or by adolescent suppression on the prevalence of spontaneous autoimmune thyroiditis (AIT) in rats.METHODS: Bio-Breeding/Worcester (BB) rats were treated neonatally with sodium iodine (NaI) or thyroid stimulating hormone (TSH), or during adolescence by triiodothyronine (T(3)), and the lymphocytic infiltration in the thyroid gland was evaluated.RESULTS: Neonatal treatment with NaI decreased the prevalence of AIT to 32+/-9% compared with 66+/-5% in the controls (P<0.002), mainly caused by a reduction among the female rats (13+/-9% vs 52+/-8%, P<0.006). TSH had no effect. Post neonatal suppression of the thyroid gland by T(3) had a biphasic response. Early in adolescence the overall prevalence was 14+/-7% compared with 66+/-5% in the controls (P<10(-5)); for female rats AIT was prevented (0+/-0%) compared with 52+/-8% in the controls (P<0.0003) and in male rats the values were 29+/-13% compared with 80+/-6% in the controls (P<0.001). Treatment with T(3) later in adolescence increased the overall prevalence to 81+/-7% compared with 66+/-5% in the controls (not significant). For female rats the prevalence increased to 78+/-9% compared with 52+/-8% in the controls (P=0.04). The degree of thyroiditis among the affected animals was similar in all groups.CONCLUSION: Neonatal stimulation of the thyroid gland by iodine or early adolescent suppression by T(3) reduced the prevalence of AIT whereas T(3) given later increased the prevalence of thyroiditis in rats. Thyroid activity at various ages seems to be of importance for the development of autoimmune thyroiditis.

KW - Age Factors

KW - Animals

KW - Animals, Newborn

KW - Body Weight

KW - Female

KW - Male

KW - Prevalence

KW - Rats

KW - Rats, Inbred Strains

KW - Sodium Iodide/pharmacology

KW - Thyroid Gland/drug effects

KW - Thyroiditis, Autoimmune/epidemiology

KW - Thyrotropin/blood

KW - Thyroxine/blood

KW - Triiodothyronine/pharmacology

UR - https://www.scopus.com/pages/publications/4744348946

U2 - 10.1530/eje.0.1510375

DO - 10.1530/eje.0.1510375

M3 - Journal article

C2 - 15362968

SN - 0804-4643

VL - 151

SP - 375

EP - 382

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

IS - 3

ER -

Neonatal stimulation of the thyroid gland with iodine or suppression during adolescence with triiodothyronine changes the prevalence of autoimmune thyroiditis in BB rats

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