Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Neocortical Development in Brain of Young Children-A Stereological Study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Use-Dependent Plasticity in Human Primary Motor Hand Area: Synergistic Interplay Between Training and Immobilization

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Task-Modulated Cortical Representations of Natural Sound Source Categories

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Working Memory Modulation of Frontoparietal Network Connectivity in First-Episode Schizophrenia

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The Crossed Projection to the Striatum in Two Species of Monkey and in Humans: Behavioral and Evolutionary Significance

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Distinct Autoimmune Anti-α-Synuclein Antibody Patterns in Multiple System Atrophy and Parkinson’s Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Authors’ response: Association between IBD and Parkinson’s disease: seek and you shall find?

    Research output: Contribution to journalComment/debateResearchpeer-review

  3. Authors' response: Association between IBD and Parkinson's disease: seek and you shall find?

    Research output: Contribution to journalComment/debateResearch

  4. Impaired Wnt Signaling in the Prefrontal Cortex of Alzheimer's Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

The early postnatal development of neuron and glia numbers is poorly documented in human brain. Therefore we estimated using design-based stereological methods the regional volumes of neocortex and the numbers of neocortical neurons and glial cells for 10 children (4 girls and 6 boys), ranging from neonate to 3 years of age. The 10 infants had a mean of 20.7 × 109 neocortical neurons (range 18.0-24.8 × 109) estimated with a coefficient of variation (CV) = 0.11; this range is similar to adult neuron numbers. The glia populations were 10.5 × 109 oligodendrocytes (range 5.0-16.0 × 109; CV = 0.40); 5.3 × 109 astrocytes (range 2.7-8.3 × 109, CV = 0.39); and 0.32 × 109 microglia (range 0.15-0.43 × 109, CV = 0.31). Thus, the estimated mean composite number of neocortical neuron and glial cells was 36.8 × 109 (range 26.8-48.3 × 109, CV = 0.21), of which approximately one-half were glial cells. There was a significant linear increase in oligodendrocyte and astrocyte numbers during the first 3 years of life, but no change in the total number of neurons. This is in line with our expectation that the total number of neocortical neurons is already determined in mid-fetal life.

Original languageEnglish
JournalCerebral Cortex
Volume27
Issue number12
Pages (from-to)5477-5484
Number of pages8
ISSN1047-3211
DOIs
Publication statusPublished - 1 Dec 2017

    Research areas

  • Journal Article

ID: 52335722