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Neoadjuvant Chemotherapy Reduces the Treatment-free Interval After First-line Treatment in Patients With Advanced Ovarian Cancer

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  1. Minimal Access vs. Open Spine Surgery in Patients With Metastatic Spinal Cord Compression - A One-Center Randomized Controlled Trial

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  2. Long-term Survival After Surgical Treatment of Spinal Metastasis - The Predictive Role of Sex

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  3. Improving Photoprotection and Implications for 25(OH)D Formation

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  4. Lifetime UVR Dose and Skin Cancer Risk, Determined by Their Common Relation to Solar Lentigines

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  5. The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma

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  1. Noncoding RNA (ncRNA) Profile Association with Patient Outcome in Epithelial Ovarian Cancer Cases

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  2. Postoperative mobilisation as an indicator for the quality of surgical nursing care

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  3. Exploring international differences in ovarian cancer treatment: a comparison of clinical practice guidelines and patterns of care

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  4. Ovariecancerbehandling i Danmark

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BACKGROUND/AIM: The aim of the study was to compare platinum resistance and treatment-free interval (TFI) following treatment with neoadjuvant chemotherapy (NACT) and interval debulking surgery (IDS) or primary debulking surgery (PDS) in women with advanced epithelial ovarian cancer (EOC).

PATIENTS AND METHODS: The study included patients diagnosed with primary EOC, stage IIIC or IV, between 2005 and 2013. Patients were grouped according to first-line treatment (PDS vs. NACT-IDS). Date of second-line treatment initiation was used to evaluate platinum sensitivity.

RESULTS: The study population included 521 patients, of which 371 (71%) and 150 (29%) underwent PDS and NACT-IDS, respectively. We found no difference in platinum resistance between groups. Platinum-sensitive patients treated with NACT-IDS had a shorter median TFI (372 vs. 497 days, p=0.042). Similarly, patients with no residual tumor after IDS had a shorter median TFI (280 vs. 302 days, p=0.005).

CONCLUSION: NACT-IDS may shorten the TFI after first-line platinum-based chemotherapy.

Original languageEnglish
JournalAnticancer Research
Volume40
Issue number5
Pages (from-to)2765-2770
Number of pages6
ISSN0250-7005
DOIs
Publication statusPublished - May 2020

    Research areas

  • Aged, Chemotherapy, Adjuvant, Drug Resistance, Neoplasm/drug effects, Female, Humans, Logistic Models, Middle Aged, Multivariate Analysis, Neoadjuvant Therapy, Neoplasm Staging, Ovarian Neoplasms/drug therapy, Platinum/pharmacology

ID: 61424108