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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Necrotizing Soft-Tissue Infections: Clinical Features and Diagnostic Aspects

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The term necrotizing soft-tissue infection (NSTI) encompasses a heterogenous group of patients with necrotizing infections, involving any body part. NSTI is diagnosed by surgical exploration, where necrosis of the subcutaneous tissue and/or muscle tissue, undermining of the skin, thrombosis of the superficial veins, and deliquescent tissue can be seen. Patients can present with vague symptoms, and approximately half of patients experience severe pain. The clinical presentation and microbiological etiology vary according to affected body site, with NSTI located to the extremities being dominated by monomicrobial group A streptococcal infections, and NSTI located to the anogenital area dominated by polymicrobial infections. No set of diagnostic criteria exists, and suspicion of the diagnosis should come from careful clinical examination and signs of local or systemic severity. Laboratory blood values show no distinct pattern but resemble those of sepsis. Imaging can aid the diagnostic process but must not delay surgical intervention.

Original languageEnglish
Book seriesAdvances in Experimental Medicine and Biology
Volume1294
Pages (from-to)39-52
Number of pages14
ISSN0065-2598
DOIs
Publication statusPublished - 1 Jan 2020

    Research areas

  • Clinical presentation, Diagnostic aspects, Fournier’s gangrene, Microbiology, Necrotizing fasciitis, Necrotizing soft-tissue infections

ID: 61082483