Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes

P V Højberg; Pär-Ola Mikael Zander; Tina Vilsbøll; F K Knop; T Krarup; Anders Vølund; Jens Møller Holst; S Madsbad

doi:10.1007/s00125-008-0943-x

Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes

P V Højberg, Pär-Ola Mikael Zander, Tina Vilsbøll, F K Knop, T Krarup, Anders Vølund, Jens Møller Holst, S Madsbad

88 Citations (Scopus)

Abstract

The ability of glucagon-like peptide-1 (GLP-1) to enhance beta cell responsiveness to i.v. glucose is impaired in patients with type 2 diabetes mellitus compared with healthy individuals. We investigated whether 4 weeks of near normalisation of blood glucose (BG) improves the potentiation of glucose-stimulated insulin secretion by GLP-1.

Original language	English
Journal	Diabetologia
Volume	51
Issue number	4
Pages (from-to)	632-40
Number of pages	9
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-008-0943-x
Publication status	Published - 1 Apr 2008

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abstract = "The ability of glucagon-like peptide-1 (GLP-1) to enhance beta cell responsiveness to i.v. glucose is impaired in patients with type 2 diabetes mellitus compared with healthy individuals. We investigated whether 4 weeks of near normalisation of blood glucose (BG) improves the potentiation of glucose-stimulated insulin secretion by GLP-1.",

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AU - Højberg, P V

AU - Zander, Pär-Ola Mikael

AU - Vilsbøll, Tina

AU - Knop, F K

AU - Krarup, T

AU - Vølund, Anders

AU - Holst, Jens Møller

AU - Madsbad, S

PY - 2008/4/1

Y1 - 2008/4/1

N2 - The ability of glucagon-like peptide-1 (GLP-1) to enhance beta cell responsiveness to i.v. glucose is impaired in patients with type 2 diabetes mellitus compared with healthy individuals. We investigated whether 4 weeks of near normalisation of blood glucose (BG) improves the potentiation of glucose-stimulated insulin secretion by GLP-1.

AB - The ability of glucagon-like peptide-1 (GLP-1) to enhance beta cell responsiveness to i.v. glucose is impaired in patients with type 2 diabetes mellitus compared with healthy individuals. We investigated whether 4 weeks of near normalisation of blood glucose (BG) improves the potentiation of glucose-stimulated insulin secretion by GLP-1.

UR - https://www.scopus.com/pages/publications/41149088656

U2 - 10.1007/s00125-008-0943-x

DO - 10.1007/s00125-008-0943-x

M3 - Journal article

C2 - 18292985

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VL - 51

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JO - Diabetologia

JF - Diabetologia

IS - 4

ER -

Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes

Abstract

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