Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Natural history and mechanisms of COPD

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. Predictive value of control of COPD for risk of exacerbations: An international, prospective study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Letter from Denmark

    Research output: Contribution to journalLetterResearchpeer-review

  3. Increased risk of major adverse cardiac events following the onset of acute exacerbations of COPD

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Importance of oesophageal ultrasound in mediastinal staging of lung cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Risk and impact of chronic cough in obese individuals from the general population

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Discordant diagnostic criteria for pneumonia in COPD trials: a review

    Research output: Contribution to journalReviewResearchpeer-review

  • Peter Lange
  • Engi Ahmed
  • Zakaria Mohamed Lahmar
  • Fernando J Martinez
  • Arnaud Bourdin
View graph of relations

The natural history of COPD is complex, and the disease is best understood as a syndrome resulting from numerous interacting factors throughout the life cycle with smoking being the strongest inciting feature. Unfortunately, diagnosis is often delayed with several longitudinal cohort studies shedding light on the long 'preclinical' period of COPD. It is now accepted that individuals presenting with different COPD phenotypes may experience varying natural history of their disease. This includes its inception, early stages and progression to established disease. Several scenarios regarding lung function course are possible, but it may conceptually be helpful to distinguish between individuals with normal maximally attained lung function in their early adulthood who thereafter experience faster than normal FEV1 decline, and those who may achieve a lower than normal maximally attained lung function. This may be the main mechanism behind COPD in the latter group, as the decline in FEV1 during their adult life may be normal or only slightly faster than normal. Regardless of the FEV1 trajectory, continuous smoking is strongly associated with disease progression, development of structural lung disease and poor prognosis. In developing countries, factors such as exposure to biomass and sequelae after tuberculosis may lead to a more airway-centred COPD phenotype than seen in smokers. Mechanistically, COPD is characterized by a combination of structural and inflammatory changes. It is unlikely that all patients share the same individual or combined mechanisms given the heterogeneity of resultant phenotypes. Lung explants, bronchial biopsies and other tissue studies have revealed important features. At the small airway level, progression of COPD is clinically imperceptible, and the pathological course of the disease is poorly described. Asthmatic features can further add confusion. However, the small airway epithelium is likely to represent a key focus of the disease, combining impaired subepithelial crosstalk and structural/inflammatory changes. Insufficient resolution of inflammatory processes may facilitate these changes. Pathologically, epithelial metaplasia, inversion of the goblet to ciliated cell ratio, enlargement of the submucosal glands and neutrophil and CD8-T-cell infiltration can be detected. Evidence of type 2 inflammation is gaining interest in the light of new therapeutic agents. Alarmin biology is a promising area that may permit control of inflammation and partial reversal of structural changes in COPD. Here, we review the latest work describing the development and progression of COPD with a focus on lung function trajectories, exacerbations and survival. We also review mechanisms focusing on epithelial changes associated with COPD and lack of resolution characterizing the underlying inflammatory processes.

Original languageEnglish
JournalRespirology (Carlton, Vic.)
Volume26
Issue number4
Pages (from-to)298-321
Number of pages24
ISSN1323-7799
DOIs
Publication statusPublished - Apr 2021

Bibliographical note

© 2021 Asian Pacific Society of Respirology.

    Research areas

  • Adult, Asthma, Humans, Longitudinal Studies, Lung, Pulmonary Disease, Chronic Obstructive, Smoking/adverse effects

ID: 74736369