Natural CD4+ T-cell responses against indoleamine 2,3-dioxygenase

Shamaila Munir; Stine Kiaer Larsen; Trine Zeeberg Iversen; Marco Donia; Tobias Wirenfeldt Klausen; Inge Marie Svane; Per  thor Straten; Mads Hald Andersen

doi:10.1371/journal.pone.0034568

Natural CD4+ T-cell responses against indoleamine 2,3-dioxygenase

Shamaila Munir, Stine Kiaer Larsen, Trine Zeeberg Iversen, Marco Donia, Tobias Wirenfeldt Klausen, Inge Marie Svane, Per thor Straten, Mads Hald Andersen

52 Citations (Scopus)

Abstract

The enzyme indoleamine 2,3-dioxygenase (IDO) contributes to immune tolerance in a variety of settings. In cancer IDO is expressed within the tumor itself as well as in antigen-presenting cells in tumor-draining lymph nodes, where it endorses the establishment of peripheral immune tolerance to tumor antigens. Recently, we described cytotoxic CD8(+) T-cell reactivity towards IDO-derived peptides.

Original language	English
Journal	P L o S One
Volume	7
Issue number	4
Pages (from-to)	e34568
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0034568
Publication status	Published - 2012

Keywords

Aged
Antineoplastic Agents
CD8-Positive T-Lymphocytes
Epitopes
Female
HLA-A2 Antigen
Histocompatibility Antigens Class II
Humans
Indoleamine-Pyrrole 2,3,-Dioxygenase
Interferon-gamma
Interleukin-10
Interleukin-17
Male
Melanoma
Middle Aged
Peptides
T-Lymphocytes, Helper-Inducer
Tumor Necrosis Factor-alpha

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title = "Natural CD4+ T-cell responses against indoleamine 2,3-dioxygenase",

abstract = "The enzyme indoleamine 2,3-dioxygenase (IDO) contributes to immune tolerance in a variety of settings. In cancer IDO is expressed within the tumor itself as well as in antigen-presenting cells in tumor-draining lymph nodes, where it endorses the establishment of peripheral immune tolerance to tumor antigens. Recently, we described cytotoxic CD8(+) T-cell reactivity towards IDO-derived peptides.",

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AU - Munir, Shamaila

AU - Larsen, Stine Kiaer

AU - Iversen, Trine Zeeberg

AU - Donia, Marco

AU - Klausen, Tobias Wirenfeldt

AU - Svane, Inge Marie

AU - thor Straten, Per

AU - Andersen, Mads Hald

PY - 2012

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KW - Epitopes

KW - Female

KW - HLA-A2 Antigen

KW - Histocompatibility Antigens Class II

KW - Humans

KW - Indoleamine-Pyrrole 2,3,-Dioxygenase

KW - Interferon-gamma

KW - Interleukin-10

KW - Interleukin-17

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DO - 10.1371/journal.pone.0034568

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JO - P L o S One

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IS - 4

ER -

Natural CD4+ T-cell responses against indoleamine 2,3-dioxygenase

Abstract

Keywords

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