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The Capital Region of Denmark - a part of Copenhagen University Hospital

Nationwide trends in the prescription of beta-blockers and angiotensin-converting enzyme inhibitors after myocardial infarction in Denmark, 1995-2002

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OBJECTIVES: To study the use of beta-blockers and angiotensin-converting enzyme (ACE) inhibitors after acute myocardial infarction (AMI) in Denmark from 1995 to 2002.

DESIGN: Information about patients with first AMI aged > or = 30 years and the dispensing of beta-blockers and ACE inhibitors from pharmacies within 30 d from discharge was obtained from the National Patient Registry and the Danish Registry of Medicinal Product Statistics.

RESULTS: Beta-blocker use increased from 38.1% of patients in 1995 to 67.9% in 2002 (OR = 3.85, CI: 3.58-4.13). Women, elderly patients and patients taking loop-diuretics and antidiabetic drugs received beta-blockers less frequently, but patients taking loop-diuretics or antidiabetic drugs had the greatest increase. ACE inhibitor use increased from 24.5 to 35.5% (OR = 1.86, CI: 1.72-2.01). Women, patients aged < 60 years or > or = 80 years and patients not taking loop-diuretics received ACE inhibitors less frequently, but patients not taking loop-diuretics had the greatest increase.

CONCLUSIONS: Beta-blocker use increased markedly post-AMI from 1995 to 2002, whereas ACE inhibitor use increased modestly. The results suggested undertreatment of women, elderly patients and people with diabetes.

Original languageEnglish
JournalScandinavian cardiovascular journal : SCJ
Issue number1-2
Pages (from-to)42-9
Number of pages8
Publication statusPublished - Apr 2005

    Research areas

  • Adrenergic beta-Antagonists, Age Factors, Angiotensin-Converting Enzyme Inhibitors, Confidence Intervals, Coronary Angiography, Coronary Restenosis, Denmark, Drug Utilization, Female, Follow-Up Studies, Health Care Surveys, Humans, Incidence, Male, Myocardial Infarction, Odds Ratio, Practice Patterns, Physicians', Probability, Registries, Sensitivity and Specificity, Severity of Illness Index, Sex Factors, Survival Rate, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't

ID: 49503265