Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

National screening guidelines and developments in prenatal diagnoses and live births of Down syndrome in the period 1973-2016 in Denmark

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Induction of labor with high- or low-dosage oral misoprostol - a Danish descriptive retrospective cohort study 2015-16

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Maternal age and risk of cesarean section in women with induced labor at term - a Nordic register-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Continuous focus on preventive strategies and follow-up is important for a change

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Androgent insensitivitetssyndrom opdaget pga. diskordans mellem prænatale vurderinger af fosterkøn.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Androgen insensitivity syndrome discovered due to discordance in prenatal assessments of fetal gender

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Balanced translocation in a patient with abortus habitualis and normal karyotype

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Mortality and morbidity of major congenital heart disease related to general prenatal screening for malformations

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

INTRODUCTION: Denmark was the first country in the world to implement a national, free-for-all offer of prenatal screening for Down syndrome to all pregnant women. It has a high uptake (> 90%) compared to other countries. Thus, Denmark offers an interesting case for investigating the consequences of implementing a comprehensive, national prenatal screening guideline. The aim of this study was to describe the historical developments in invasive procedures, pre-/postnatal diagnoses of Down syndrome and Down syndrome live births in the period 1973-2016 in Denmark MATERIAL AND METHODS: Data on invasive procedures, pre- and postnatal Down syndrome diagnoses were retrieved from the Danish Cytogenetic Central Registry RESULTS: From 1973-1993 screening based on maternal age and high-risk indications resulted in a constant increase in invasive procedures. After the introduction of the triple test in 1994, invasive procedures decreased for the first time in 20 years. Following the introduction of an offer of combined screening to all pregnant women in 2004, the number of invasive procedures decreased markedly while there was a concurrent increase in prenatal diagnoses of Down syndrome. Additionally, the number of Down syndrome live births decreased suddenly and significantly, but subsequently stabilized at 23-35 annual live births. Of these, the majority was diagnosed postnatally CONCLUSIONS: Though prenatal screening technologies constantly improve, it is the introduction of and adherence to national guidelines that resulted in marked shifts in screening procedures and outcome in Denmark. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalActa Obstetricia et Gynecologica Scandinavica
Volume97
Issue number2
Pages (from-to)195-203
ISSN0001-6349
DOIs
Publication statusPublished - 2018

    Research areas

  • Journal Article

ID: 52090678