Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring

Ludwig Kappos; David Bates; Gilles Edan; Mefkûre Eraksoy; Antonio Garcia-Merino; Nikolaos Grigoriadis; Hans-Peter Hartung; Eva Havrdová; Jan Hillert; Reinhard Hohlfeld; Marcelo Kremenchutzky; Olivier Lyon-Caen; Ariel Miller; Carlo Pozzilli; Mads Ravnborg; Takahiko Saida; Christian Sindic; Karl Vass; David B Clifford; Stephen Hauser; Eugene O Major; Paul W O'Connor; Howard L Weiner; Michel Clanet; Ralf Gold; Hans H Hirsch; Ernst-Wilhelm Radü; Per Soelberg Sørensen; John King

doi:10.1016/S1474-4422(11)70149-1

Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring

Ludwig Kappos, David Bates, Gilles Edan, Mefkûre Eraksoy, Antonio Garcia-Merino, Nikolaos Grigoriadis, Hans-Peter Hartung, Eva Havrdová, Jan Hillert, Reinhard Hohlfeld, Marcelo Kremenchutzky, Olivier Lyon-Caen, Ariel Miller, Carlo Pozzilli, Mads Ravnborg, Takahiko Saida, Christian Sindic, Karl Vass, David B Clifford, Stephen HauserEugene O Major, Paul W O'Connor, Howard L Weiner, Michel Clanet, Ralf Gold, Hans H Hirsch, Ernst-Wilhelm Radü, Per Soelberg Sørensen, John King

Department of Neurology

259 Citations (Scopus)

Abstract

Natalizumab, a highly specific α4-integrin antagonist, is approved for treatment of patients with active relapsing-remitting multiple sclerosis (RRMS). It is generally recommended for individuals who have not responded to a currently available first-line disease-modifying therapy or who have very active disease. The expected benefits of natalizumab treatment have to be weighed against risks, especially the rare but serious adverse event of progressive multifocal leukoencephalopathy. In this Review, we revisit and update previous recommendations on natalizumab for treatment of patients with RRMS, based on additional long-term follow-up of clinical studies and post-marketing observations, including appropriate patient selection and management recommendations.

Original language	English
Journal	Lancet neurology
Volume	10
Issue number	8
Pages (from-to)	745-58
Number of pages	14
ISSN	1474-4422
DOIs	https://doi.org/10.1016/S1474-4422(11)70149-1
Publication status	Published - 2011

Keywords

Animals
Antibodies, Monoclonal
Antibodies, Monoclonal, Humanized
Drug Monitoring
Humans
Integrin alpha4beta1
Leukoencephalopathy, Progressive Multifocal
Multiple Sclerosis, Relapsing-Remitting
Patient Selection
Practice Guidelines as Topic
Treatment Outcome

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Kappos, L., Bates, D., Edan, G., Eraksoy, M., Garcia-Merino, A., Grigoriadis, N., Hartung, H.-P., Havrdová, E., Hillert, J., Hohlfeld, R., Kremenchutzky, M., Lyon-Caen, O., Miller, A., Pozzilli, C., Ravnborg, M., Saida, T., Sindic, C., Vass, K., Clifford, D. B., ... King, J. (2011). Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring. Lancet neurology, 10(8), 745-58. https://doi.org/10.1016/S1474-4422(11)70149-1

Kappos, L, Bates, D, Edan, G, Eraksoy, M, Garcia-Merino, A, Grigoriadis, N, Hartung, H-P, Havrdová, E, Hillert, J, Hohlfeld, R, Kremenchutzky, M, Lyon-Caen, O, Miller, A, Pozzilli, C, Ravnborg, M, Saida, T, Sindic, C, Vass, K, Clifford, DB, Hauser, S, Major, EO, O'Connor, PW, Weiner, HL, Clanet, M, Gold, R, Hirsch, HH, Radü, E-W, Sørensen, PS & King, J 2011, 'Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring', Lancet neurology, vol. 10, no. 8, pp. 745-58. https://doi.org/10.1016/S1474-4422(11)70149-1

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abstract = "Natalizumab, a highly specific α4-integrin antagonist, is approved for treatment of patients with active relapsing-remitting multiple sclerosis (RRMS). It is generally recommended for individuals who have not responded to a currently available first-line disease-modifying therapy or who have very active disease. The expected benefits of natalizumab treatment have to be weighed against risks, especially the rare but serious adverse event of progressive multifocal leukoencephalopathy. In this Review, we revisit and update previous recommendations on natalizumab for treatment of patients with RRMS, based on additional long-term follow-up of clinical studies and post-marketing observations, including appropriate patient selection and management recommendations.",

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AU - Grigoriadis, Nikolaos

AU - Hartung, Hans-Peter

AU - Havrdová, Eva

AU - Hillert, Jan

AU - Hohlfeld, Reinhard

AU - Kremenchutzky, Marcelo

AU - Lyon-Caen, Olivier

AU - Miller, Ariel

AU - Pozzilli, Carlo

AU - Ravnborg, Mads

AU - Saida, Takahiko

AU - Sindic, Christian

AU - Vass, Karl

AU - Clifford, David B

AU - Hauser, Stephen

AU - Major, Eugene O

AU - O'Connor, Paul W

AU - Weiner, Howard L

AU - Clanet, Michel

AU - Gold, Ralf

AU - Hirsch, Hans H

AU - Radü, Ernst-Wilhelm

AU - Sørensen, Per Soelberg

AU - King, John

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AB - Natalizumab, a highly specific α4-integrin antagonist, is approved for treatment of patients with active relapsing-remitting multiple sclerosis (RRMS). It is generally recommended for individuals who have not responded to a currently available first-line disease-modifying therapy or who have very active disease. The expected benefits of natalizumab treatment have to be weighed against risks, especially the rare but serious adverse event of progressive multifocal leukoencephalopathy. In this Review, we revisit and update previous recommendations on natalizumab for treatment of patients with RRMS, based on additional long-term follow-up of clinical studies and post-marketing observations, including appropriate patient selection and management recommendations.

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KW - Patient Selection

KW - Practice Guidelines as Topic

KW - Treatment Outcome

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JF - Lancet neurology

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Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring

Abstract

Keywords

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