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Nasal insulin administration does not affect hepatic glucose production at systemic fasting insulin levels

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@article{5999bbf46d314b59b028e0718f96cbb8,
title = "Nasal insulin administration does not affect hepatic glucose production at systemic fasting insulin levels",
abstract = "AIMS: To evaluate the effects of brain insulin on endogenous glucose production in fasting humans, with a focus on hepatic glucose release by performing a randomized, placebo-controlled, blinded, crossover experiment.MATERIALS AND METHODS: On two separate days, 2 H2 -glucose was infused to nine healthy lean men, and blood was sampled from the hepatic vein and a radial artery. On day 1, participants received 160 U human insulin through nasal spray, and on day 2 they received placebo spray, together with an intravenous insulin bolus to mimic spillover of nasal insulin to the circulation. Hepatic glucose fluxes and endogenous glucose production were calculated.RESULTS: Plasma insulin concentrations were similar on the two study days, and no differences in whole-body endogenous glucose production or hepato-splanchnic glucose turnover were detected.CONCLUSIONS: Nasal administration of insulin does not influence whole-body or hepatic glucose production in fasting humans. By contrast, pharmacological delivery of insulin to the brain might modulate insulin effectiveness in glucose-producing tissue when circulating insulin levels are elevated; therefore, the metabolic consequences of brain insulin action appear to be dependent on metabolic prandial status.",
keywords = "basal insulin, clinical physiology, liver",
author = "Peter Plomgaard and Hansen, {Jakob S} and Bodil Ingerslev and Clemmesen, {Jens O} and Secher, {Niels H} and {van Hall}, Gerrit and Andreas Fritsche and Cora Weigert and Rainer Lehmann and Hans-Ulrich H{\"a}ring and Martin Heni",
note = "{\textcopyright} 2018 John Wiley & Sons Ltd.",
year = "2019",
doi = "10.1111/dom.13615",
language = "English",
volume = "21",
pages = "993--1000",
journal = "Diabetes, Obesity and Metabolism",
issn = "1462-8902",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "4",

}

RIS

TY - JOUR

T1 - Nasal insulin administration does not affect hepatic glucose production at systemic fasting insulin levels

AU - Plomgaard, Peter

AU - Hansen, Jakob S

AU - Ingerslev, Bodil

AU - Clemmesen, Jens O

AU - Secher, Niels H

AU - van Hall, Gerrit

AU - Fritsche, Andreas

AU - Weigert, Cora

AU - Lehmann, Rainer

AU - Häring, Hans-Ulrich

AU - Heni, Martin

N1 - © 2018 John Wiley & Sons Ltd.

PY - 2019

Y1 - 2019

N2 - AIMS: To evaluate the effects of brain insulin on endogenous glucose production in fasting humans, with a focus on hepatic glucose release by performing a randomized, placebo-controlled, blinded, crossover experiment.MATERIALS AND METHODS: On two separate days, 2 H2 -glucose was infused to nine healthy lean men, and blood was sampled from the hepatic vein and a radial artery. On day 1, participants received 160 U human insulin through nasal spray, and on day 2 they received placebo spray, together with an intravenous insulin bolus to mimic spillover of nasal insulin to the circulation. Hepatic glucose fluxes and endogenous glucose production were calculated.RESULTS: Plasma insulin concentrations were similar on the two study days, and no differences in whole-body endogenous glucose production or hepato-splanchnic glucose turnover were detected.CONCLUSIONS: Nasal administration of insulin does not influence whole-body or hepatic glucose production in fasting humans. By contrast, pharmacological delivery of insulin to the brain might modulate insulin effectiveness in glucose-producing tissue when circulating insulin levels are elevated; therefore, the metabolic consequences of brain insulin action appear to be dependent on metabolic prandial status.

AB - AIMS: To evaluate the effects of brain insulin on endogenous glucose production in fasting humans, with a focus on hepatic glucose release by performing a randomized, placebo-controlled, blinded, crossover experiment.MATERIALS AND METHODS: On two separate days, 2 H2 -glucose was infused to nine healthy lean men, and blood was sampled from the hepatic vein and a radial artery. On day 1, participants received 160 U human insulin through nasal spray, and on day 2 they received placebo spray, together with an intravenous insulin bolus to mimic spillover of nasal insulin to the circulation. Hepatic glucose fluxes and endogenous glucose production were calculated.RESULTS: Plasma insulin concentrations were similar on the two study days, and no differences in whole-body endogenous glucose production or hepato-splanchnic glucose turnover were detected.CONCLUSIONS: Nasal administration of insulin does not influence whole-body or hepatic glucose production in fasting humans. By contrast, pharmacological delivery of insulin to the brain might modulate insulin effectiveness in glucose-producing tissue when circulating insulin levels are elevated; therefore, the metabolic consequences of brain insulin action appear to be dependent on metabolic prandial status.

KW - basal insulin

KW - clinical physiology

KW - liver

U2 - 10.1111/dom.13615

DO - 10.1111/dom.13615

M3 - Journal article

C2 - 30552787

VL - 21

SP - 993

EP - 1000

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

SN - 1462-8902

IS - 4

ER -

ID: 56502264