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The Capital Region of Denmark - a part of Copenhagen University Hospital
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N-[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, a molecule for radiohalogenation of proteins and peptides

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  1. 68Ga-autoclabeling of DOTA-TATE and DOTA-NOC

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  2. A simple method for the quality control of [(18)F]FDG

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  1. Extraction of 211At from nitric acid solutions into various organic solvents for use as an α-source for radiation chemistry studies

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  2. Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates

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  3. Absorbed Doses and Risk Estimates of (211)At-MX35 F(ab')2 in Intraperitoneal Therapy of Ovarian Cancer Patients

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  4. Shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates, precursors for 211At labeling of antibodies

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In this work a new coupling reagent, N-[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, for radiohalogenation has been synthesized and characterized. The reagent is intended to either be attached to reduced disulfide bridges of proteins (making the halogenation site-specific) or to free terminal cysteine groups on peptides. The new reagent was also shown to be easily halogenated with inactive bromine and iodine as well as (125)I and (211)At, indicating potential use within targeted radiotherapy.

Original languageEnglish
JournalApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Volume96
Pages (from-to)1-5
Number of pages5
ISSN0969-8043
DOIs
Publication statusPublished - Feb 2015

    Research areas

  • Astatine, Benzamides, Bromine, Chromatography, High Pressure Liquid, Halogenation, Humans, Indicators and Reagents, Iodine Radioisotopes, Molecular Structure, Organotin Compounds, Peptides, Proteins, Radiopharmaceuticals

ID: 46266277