N-terminal pro-C-type natriuretic peptide in serum associated with bone destruction in patients with multiple myeloma

Anne K Mylin; Jens P Goetze; Lene Heickendorff; Lucia Ahlberg; Inger Marie Dahl; Niels Abildgaard; Peter Gimsing; Nordic Myeloma Study Group

doi:10.2217/bmm.15.35

N-terminal pro-C-type natriuretic peptide in serum associated with bone destruction in patients with multiple myeloma

Anne K Mylin, Jens P Goetze, Lene Heickendorff, Lucia Ahlberg, Inger Marie Dahl, Niels Abildgaard, Peter Gimsing, Nordic Myeloma Study Group

Clinical Chemistry, Department of

5 Citations (Scopus)

Abstract

AIM: To examine whether N-terminal proCNP concentrations in serum is associated with bone destruction in patients with multiple myeloma.

MATERIALS & METHODS: N-terminal proCNP and biochemical bone markers were measured in 153 patients. Radiographic bone disease and skeletal-related events were evaluated at specific time-points.

RESULTS: N-terminal proCNP concentrations increased with age. High N-terminal proCNP concentrations were associated with high-risk disease and renal impairment. Renal function explained 22% of the variation. N-terminal proCNP concentrations correlated with serum bone ALP and serum PINP, but lacked association with bone resorption markers, radiographic bone disease and skeletal-related events.

CONCLUSION: Serum N-terminal proCNP are associated with bone formation activity in patients with multiple myeloma, but should be interpreted with caution in patients with renal impairment.

Original language	English
Journal	Biomarkers in Medicine
Volume	9
Issue number	7
Pages (from-to)	679-89
Number of pages	11
ISSN	1752-0363
DOIs	https://doi.org/10.2217/bmm.15.35
Publication status	Published - 2015

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title = "N-terminal pro-C-type natriuretic peptide in serum associated with bone destruction in patients with multiple myeloma",

abstract = "AIM: To examine whether N-terminal proCNP concentrations in serum is associated with bone destruction in patients with multiple myeloma.MATERIALS & METHODS: N-terminal proCNP and biochemical bone markers were measured in 153 patients. Radiographic bone disease and skeletal-related events were evaluated at specific time-points.RESULTS: N-terminal proCNP concentrations increased with age. High N-terminal proCNP concentrations were associated with high-risk disease and renal impairment. Renal function explained 22% of the variation. N-terminal proCNP concentrations correlated with serum bone ALP and serum PINP, but lacked association with bone resorption markers, radiographic bone disease and skeletal-related events.CONCLUSION: Serum N-terminal proCNP are associated with bone formation activity in patients with multiple myeloma, but should be interpreted with caution in patients with renal impairment.",

author = "Mylin, {Anne K} and Goetze, {Jens P} and Lene Heickendorff and Lucia Ahlberg and Dahl, {Inger Marie} and Niels Abildgaard and Peter Gimsing and {Nordic Myeloma Study Group}",

year = "2015",

doi = "10.2217/bmm.15.35",

language = "English",

volume = "9",

pages = "679--89",

journal = "Biomarker Research",

issn = "2050-7771",

publisher = "BioMed Central Ltd",

number = "7",

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TY - JOUR

T1 - N-terminal pro-C-type natriuretic peptide in serum associated with bone destruction in patients with multiple myeloma

AU - Mylin, Anne K

AU - Goetze, Jens P

AU - Heickendorff, Lene

AU - Ahlberg, Lucia

AU - Dahl, Inger Marie

AU - Abildgaard, Niels

AU - Gimsing, Peter

AU - Nordic Myeloma Study Group

PY - 2015

Y1 - 2015

N2 - AIM: To examine whether N-terminal proCNP concentrations in serum is associated with bone destruction in patients with multiple myeloma.MATERIALS & METHODS: N-terminal proCNP and biochemical bone markers were measured in 153 patients. Radiographic bone disease and skeletal-related events were evaluated at specific time-points.RESULTS: N-terminal proCNP concentrations increased with age. High N-terminal proCNP concentrations were associated with high-risk disease and renal impairment. Renal function explained 22% of the variation. N-terminal proCNP concentrations correlated with serum bone ALP and serum PINP, but lacked association with bone resorption markers, radiographic bone disease and skeletal-related events.CONCLUSION: Serum N-terminal proCNP are associated with bone formation activity in patients with multiple myeloma, but should be interpreted with caution in patients with renal impairment.

AB - AIM: To examine whether N-terminal proCNP concentrations in serum is associated with bone destruction in patients with multiple myeloma.MATERIALS & METHODS: N-terminal proCNP and biochemical bone markers were measured in 153 patients. Radiographic bone disease and skeletal-related events were evaluated at specific time-points.RESULTS: N-terminal proCNP concentrations increased with age. High N-terminal proCNP concentrations were associated with high-risk disease and renal impairment. Renal function explained 22% of the variation. N-terminal proCNP concentrations correlated with serum bone ALP and serum PINP, but lacked association with bone resorption markers, radiographic bone disease and skeletal-related events.CONCLUSION: Serum N-terminal proCNP are associated with bone formation activity in patients with multiple myeloma, but should be interpreted with caution in patients with renal impairment.

U2 - 10.2217/bmm.15.35

DO - 10.2217/bmm.15.35

M3 - Journal article

C2 - 26174842

VL - 9

SP - 679

EP - 689

JO - Biomarker Research

JF - Biomarker Research

SN - 2050-7771

IS - 7

ER -

N-terminal pro-C-type natriuretic peptide in serum associated with bone destruction in patients with multiple myeloma

Abstract

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