Myocardial impulse propagation is impaired in right ventricular tissue of Zucker diabetic fatty (ZDF) rats

Kristine Boisen Olsen; Lene Nygaard Axelsen; Thomas Hartig Braunstein; Charlotte Mehlin Sørensen; Claus B Andersen; Thorkil Ploug; Niels-Henrik Holstein-Rathlou; Morten Schak Nielsen

doi:10.1186/1475-2840-12-19

Myocardial impulse propagation is impaired in right ventricular tissue of Zucker diabetic fatty (ZDF) rats

Kristine Boisen Olsen, Lene Nygaard Axelsen, Thomas Hartig Braunstein, Charlotte Mehlin Sørensen, Claus B Andersen, Thorkil Ploug, Niels-Henrik Holstein-Rathlou, Morten Schak Nielsen

Department of Pathology

29 Citations (Scopus)

Abstract

Diabetes increases the risk of cardiovascular complications including arrhythmias, but the underlying mechanisms remain to be established. Decreased conduction velocity (CV), which is an independent risk factor for re-entry arrhythmias, is present in models with streptozotocin (STZ) induced type 1 diabetes. Whether CV is also disturbed in models of type 2 diabetes is currently unknown.

Original language	English
Journal	Cardiovascular Diabetology
Volume	12
Pages (from-to)	19
ISSN	1475-2840
DOIs	https://doi.org/10.1186/1475-2840-12-19
Publication status	Published - 2013

Keywords

Animals
Diabetes Mellitus, Type 2
Heart
Heart Conduction System
Heart Ventricles
Male
Myocardium
Organ Culture Techniques
Rats
Rats, Zucker

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10.1186/1475-2840-12-19

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title = "Myocardial impulse propagation is impaired in right ventricular tissue of Zucker diabetic fatty (ZDF) rats",

abstract = "Diabetes increases the risk of cardiovascular complications including arrhythmias, but the underlying mechanisms remain to be established. Decreased conduction velocity (CV), which is an independent risk factor for re-entry arrhythmias, is present in models with streptozotocin (STZ) induced type 1 diabetes. Whether CV is also disturbed in models of type 2 diabetes is currently unknown.",

keywords = "Animals, Diabetes Mellitus, Type 2, Heart, Heart Conduction System, Heart Ventricles, Male, Myocardium, Organ Culture Techniques, Rats, Rats, Zucker",

author = "Olsen, \{Kristine Boisen\} and Axelsen, \{Lene Nygaard\} and Braunstein, \{Thomas Hartig\} and S{\o}rensen, \{Charlotte Mehlin\} and Andersen, \{Claus B\} and Thorkil Ploug and Niels-Henrik Holstein-Rathlou and Nielsen, \{Morten Schak\}",

year = "2013",

doi = "10.1186/1475-2840-12-19",

language = "English",

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journal = "Cardiovascular Diabetology",

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T1 - Myocardial impulse propagation is impaired in right ventricular tissue of Zucker diabetic fatty (ZDF) rats

AU - Olsen, Kristine Boisen

AU - Axelsen, Lene Nygaard

AU - Braunstein, Thomas Hartig

AU - Sørensen, Charlotte Mehlin

AU - Andersen, Claus B

AU - Ploug, Thorkil

AU - Holstein-Rathlou, Niels-Henrik

AU - Nielsen, Morten Schak

PY - 2013

Y1 - 2013

N2 - Diabetes increases the risk of cardiovascular complications including arrhythmias, but the underlying mechanisms remain to be established. Decreased conduction velocity (CV), which is an independent risk factor for re-entry arrhythmias, is present in models with streptozotocin (STZ) induced type 1 diabetes. Whether CV is also disturbed in models of type 2 diabetes is currently unknown.

AB - Diabetes increases the risk of cardiovascular complications including arrhythmias, but the underlying mechanisms remain to be established. Decreased conduction velocity (CV), which is an independent risk factor for re-entry arrhythmias, is present in models with streptozotocin (STZ) induced type 1 diabetes. Whether CV is also disturbed in models of type 2 diabetes is currently unknown.

KW - Animals

KW - Diabetes Mellitus, Type 2

KW - Heart

KW - Heart Conduction System

KW - Heart Ventricles

KW - Male

KW - Myocardium

KW - Organ Culture Techniques

KW - Rats

KW - Rats, Zucker

UR - https://www.scopus.com/pages/publications/84872273146

U2 - 10.1186/1475-2840-12-19

DO - 10.1186/1475-2840-12-19

M3 - Journal article

C2 - 23327647

SN - 1475-2840

VL - 12

SP - 19

JO - Cardiovascular Diabetology

JF - Cardiovascular Diabetology

ER -

Myocardial impulse propagation is impaired in right ventricular tissue of Zucker diabetic fatty (ZDF) rats

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Keywords

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