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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Mutation of KRAS in colorectal adenocarcinoma in Greenland

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KRAS mutation is one of the most frequent driver mutations in colorectal cancer (CRC) and is also a prognostic biomarker. The aim of the present study was to determine the frequency of KRAS mutations over time in the Greenlandic population diagnosed with CRC. In total, 578 patients with the diagnosis of adenocarcinoma between 1988 and 2017 were identified. The status of KRAS and the mutational subtypes of KRAS mutations were determined in 102 representative samples by the Idylla™ platform in the time periods 1988-1990, 2002-2004, and 2015-2017. The results showed that the frequency of the KRAS mutations increased significantly, from 27% in 1988-1990 to 43% in 2015-2017 (p < 0.001). Furthermore, the most frequent subtypes of KRAS mutations in Greenland were G12D (c.35G > A) with 14%, G12V (c.35G > T) with 7%, and G13D (c.38G > A) with 6%. In conclusion, this study showed that the frequency of KRAS mutations in CRC has been increasing in recent decades in the specific population of Greenland. The results of this study may be used in initiatives related to targeted therapy of CRC in specific ethnicities and in investigations focusing on the environmental factors of cancer-related somatic mutations.

Original languageEnglish
JournalAPMIS - Journal of Pathology, Microbiology and Immunology
Volume130
Issue number8
Pages (from-to)493-497
Number of pages5
ISSN0903-4641
DOIs
Publication statusPublished - Aug 2022

Bibliographical note

© 2022 APMIS. Published by John Wiley & Sons Ltd.

    Research areas

  • Adenocarcinoma/pathology, Colorectal Neoplasms/genetics, Greenland/epidemiology, Humans, Mutation, Proto-Oncogene Proteins p21(ras)/genetics, Proto-Oncogene Proteins/genetics, ras Proteins/genetics, inuit, KRAS mutation, population genetics, Colorectal cancer, greenland

ID: 79118421