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Muscle contractility of leg muscles in patients with mitochondrial myopathies

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@article{9812ea3df03442d1b0379b77119e2aa8,
title = "Muscle contractility of leg muscles in patients with mitochondrial myopathies",
abstract = "BACKGROUND: The primary disease mechanism underlying mitochondrial myopathies (MM) is impaired energy generation to support muscle endurance. Little is known about muscle contractility before energy becomes deficient during muscle contractions. We investigated muscle contractility in MM to uncover potentially fixed weakness aspects of the disorders.METHODS: Contractility of calf and thigh muscles was investigated by comparing strength with contractile cross-sectional area (CCSA) of the used muscles, as measured by stationary dynamometry and MRI, respectively.RESULTS AND DISCUSSION: Our findings suggest reduced contractile properties in thigh and calf muscles of patients with MM.",
author = "Poulsen, {Nanna Scharff} and Dahlqvist, {Julia Rebecka} and Gitte Hedermann and Nicoline L{\o}kken and John Vissing",
note = "Copyright {\circledC} 2018 Elsevier B.V. and Mitochondria Research Society. All rights reserved.",
year = "2019",
month = "5",
doi = "10.1016/j.mito.2018.07.001",
language = "English",
volume = "46",
pages = "221--227",
journal = "Mitochondrion",
issn = "1567-7249",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Muscle contractility of leg muscles in patients with mitochondrial myopathies

AU - Poulsen, Nanna Scharff

AU - Dahlqvist, Julia Rebecka

AU - Hedermann, Gitte

AU - Løkken, Nicoline

AU - Vissing, John

N1 - Copyright © 2018 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

PY - 2019/5

Y1 - 2019/5

N2 - BACKGROUND: The primary disease mechanism underlying mitochondrial myopathies (MM) is impaired energy generation to support muscle endurance. Little is known about muscle contractility before energy becomes deficient during muscle contractions. We investigated muscle contractility in MM to uncover potentially fixed weakness aspects of the disorders.METHODS: Contractility of calf and thigh muscles was investigated by comparing strength with contractile cross-sectional area (CCSA) of the used muscles, as measured by stationary dynamometry and MRI, respectively.RESULTS AND DISCUSSION: Our findings suggest reduced contractile properties in thigh and calf muscles of patients with MM.

AB - BACKGROUND: The primary disease mechanism underlying mitochondrial myopathies (MM) is impaired energy generation to support muscle endurance. Little is known about muscle contractility before energy becomes deficient during muscle contractions. We investigated muscle contractility in MM to uncover potentially fixed weakness aspects of the disorders.METHODS: Contractility of calf and thigh muscles was investigated by comparing strength with contractile cross-sectional area (CCSA) of the used muscles, as measured by stationary dynamometry and MRI, respectively.RESULTS AND DISCUSSION: Our findings suggest reduced contractile properties in thigh and calf muscles of patients with MM.

UR - http://www.scopus.com/inward/record.url?scp=85050891196&partnerID=8YFLogxK

U2 - 10.1016/j.mito.2018.07.001

DO - 10.1016/j.mito.2018.07.001

M3 - Journal article

VL - 46

SP - 221

EP - 227

JO - Mitochondrion

JF - Mitochondrion

SN - 1567-7249

ER -

ID: 55680303