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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Muscle contractility of leg muscles in patients with mitochondrial myopathies

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BACKGROUND: The primary disease mechanism underlying mitochondrial myopathies (MM) is impaired energy generation to support muscle endurance. Little is known about muscle contractility before energy becomes deficient during muscle contractions. We investigated muscle contractility in MM to uncover potentially fixed weakness aspects of the disorders.

METHODS: Contractility of calf and thigh muscles was investigated by comparing strength with contractile cross-sectional area (CCSA) of the used muscles, as measured by stationary dynamometry and MRI, respectively.

RESULTS AND DISCUSSION: Our findings suggest reduced contractile properties in thigh and calf muscles of patients with MM.

Original languageEnglish
JournalMitochondrion
Volume46
Pages (from-to)221-227
Number of pages7
ISSN1567-7249
DOIs
Publication statusPublished - May 2019

ID: 55680303