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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Muscle contractility of leg muscles in patients with mitochondrial myopathies

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy

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  2. Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always

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  1. Hydroxylated Long-Chain Acylcarnitines are Biomarkers of Mitochondrial Myopathy

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. MSTO1 mutations cause mtDNA depletion, manifesting as muscular dystrophy with cerebellar involvement

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy

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  4. Fat oxidation is impaired during exercise in lipin-1 deficiency

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BACKGROUND: The primary disease mechanism underlying mitochondrial myopathies (MM) is impaired energy generation to support muscle endurance. Little is known about muscle contractility before energy becomes deficient during muscle contractions. We investigated muscle contractility in MM to uncover potentially fixed weakness aspects of the disorders.

METHODS: Contractility of calf and thigh muscles was investigated by comparing strength with contractile cross-sectional area (CCSA) of the used muscles, as measured by stationary dynamometry and MRI, respectively.

RESULTS AND DISCUSSION: Our findings suggest reduced contractile properties in thigh and calf muscles of patients with MM.

Original languageEnglish
JournalMitochondrion
Volume46
Pages (from-to)221-227
Number of pages7
ISSN1567-7249
DOIs
Publication statusPublished - May 2019

ID: 55680303