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Multi-slice echo-planar spectroscopic MR imaging provides both global and local metabolite measures in multiple sclerosis

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  1. Quantification of cerebral perfusion and cerebrovascular reserve using Turbo-QUASAR arterial spin labeling MRI

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  2. Coil profile estimation strategies for parallel imaging with hyperpolarized 13 C MRI

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  3. Gamma-aminobutyric acid edited echo-planar spectroscopic imaging (EPSI) with MEGA-sLASER at 7T

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  4. Comparison of prospective head motion correction with NMR field probes and an optical tracking system

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  5. Improved calculation of the equilibrium magnetization of arterial blood in arterial spin labeling

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  1. Diagnostic added value of electrical source imaging in presurgical evaluation of patients with epilepsy: A prospective study

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  2. Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed

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  3. Klinisk Neurologi og Neurokirurgi

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  4. Coil profile estimation strategies for parallel imaging with hyperpolarized 13 C MRI

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MR spectroscopy (MRS) provides information about neuronal loss or dysfunction by measuring decreases in N-acetyl aspartate (NAA), a metabolite widely believed to be a marker of neuronal viability. In multiple sclerosis (MS), whole-brain NAA (WBNAA) has been suggested as a marker of disease progression and treatment efficacy in treatment trials, and the ability to measure NAA loss in specific brain regions early in the evolution of this disease may have prognostic value. Most spectroscopic studies to date have been limited to single voxels or nonlocalized measurements of WBNAA only, and longitudinal studies have often been hampered by standardization and reproducibility problems. Multi-slice echo-planar spectroscopic imaging (EPSI) is presented as a promising alternative to single-voxel or nonlocalized spectroscopy for obtaining global metabolite estimates in MS. In the same session, measurements of metabolites in specific brain areas chosen after image acquisition (e.g., normal-appearing white matter (NAWM), gray matter (GM), and lesions) can be obtained. The identification and exclusion of regions that are inadequate for spectroscopic evaluation in global assessments can significantly improve quality and reproducibility, as demonstrated by a low within-subject variance in healthy controls. The reproducibility of the technique makes it a promising tool for future longitudinal spectroscopic studies of MS.
Original languageEnglish
JournalMagnetic Resonance in Medicine
Volume53
Issue number4
Pages (from-to)750-9
Number of pages9
ISSN0740-3194
DOIs
Publication statusPublished - 2005

    Research areas

  • Adult, Aspartic Acid, Brain, Case-Control Studies, Choline, Creatine, Echo-Planar Imaging, Female, Humans, Magnetic Resonance Spectroscopy, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting

ID: 32568521