Multirater Validation of Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS)

Axel Petzold; Valerie Biousse; Lulu Bursztyn; Fiona Costello; Alison Crum; Kathleen Digre; Clare Fraser; J Alex Fraser; Bradley Katz; Neringa Jurkute; Nancy Newman; Jette Lautrup-Battistini; Mitchell Lawlor; Petra Liskova; Birgit Lorenz; Lasse Malmqvist; Jason Peragallo; Patrick Sibony; Prem Subramanian; Robert Rejdak; Katarzyna Nowomiejska; Valerie Touitou; Judith Warner; Marianne Wegener; Sui Wong; Patrick Yu-Wai-Man; Steffen Hamann

doi:10.1080/01658107.2020.1760891

Multirater Validation of Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS)

Axel Petzold, Valerie Biousse, Lulu Bursztyn, Fiona Costello, Alison Crum, Kathleen Digre, Clare Fraser, J Alex Fraser, Bradley Katz, Neringa Jurkute, Nancy Newman, Jette Lautrup-Battistini, Mitchell Lawlor, Petra Liskova, Birgit Lorenz, Lasse Malmqvist, Jason Peragallo, Patrick Sibony, Prem Subramanian, Robert RejdakKatarzyna Nowomiejska, Valerie Touitou, Judith Warner, Marianne Wegener, Sui Wong, Patrick Yu-Wai-Man, Steffen Hamann

11 Citations (Scopus)

Abstract

Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are a new retinal optical coherence tomography (OCT) finding. The Optic Disc Drusen Studies Consortium had made recommendations to distinguish PHOMS from true optic disc drusen (ODD) in 2018. While publications on PHOMS have increased since then, the accuracy of the definition of PHOMS and reliability of detection is unknown. In this multi-rater study, we demonstrate that the 2018 definition of PHOMS resulted in a poor multi-rater kappa of 0.356. We performed a Delphi consensus process to develop a consistent and refined definition of PHOMS with clear principles around the nature of PHOMS and how they differ from normal anatomy. Fifty explanatory teaching slides, provided as supplementary material, allowed our expert group of raters to achieve a good level of agreement (kappa 0.701, 50 OCT scans, 21 raters). We recommend adopting the refined definition for PHOMS.

Original language	English
Journal	Neuro-Ophthalmology
Volume	44
Issue number	6
Pages (from-to)	413-414
Number of pages	2
ISSN	0165-8107
DOIs	https://doi.org/10.1080/01658107.2020.1760891
Publication status	Published - 2020

Keywords

OCT
ODD
PHOMS

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Petzold, A., Biousse, V., Bursztyn, L., Costello, F., Crum, A., Digre, K., Fraser, C., Fraser, J. A., Katz, B., Jurkute, N., Newman, N., Lautrup-Battistini, J., Lawlor, M., Liskova, P., Lorenz, B., Malmqvist, L., Peragallo, J., Sibony, P., Subramanian, P., ... Hamann, S. (2020). Multirater Validation of Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS). Neuro-Ophthalmology, 44(6), 413-414. https://doi.org/10.1080/01658107.2020.1760891

Petzold, A, Biousse, V, Bursztyn, L, Costello, F, Crum, A, Digre, K, Fraser, C, Fraser, JA, Katz, B, Jurkute, N, Newman, N, Lautrup-Battistini, J, Lawlor, M, Liskova, P, Lorenz, B, Malmqvist, L, Peragallo, J, Sibony, P, Subramanian, P, Rejdak, R, Nowomiejska, K, Touitou, V, Warner, J, Wegener, M, Wong, S, Yu-Wai-Man, P & Hamann, S 2020, 'Multirater Validation of Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS)', Neuro-Ophthalmology, vol. 44, no. 6, pp. 413-414. https://doi.org/10.1080/01658107.2020.1760891

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abstract = "Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are a new retinal optical coherence tomography (OCT) finding. The Optic Disc Drusen Studies Consortium had made recommendations to distinguish PHOMS from true optic disc drusen (ODD) in 2018. While publications on PHOMS have increased since then, the accuracy of the definition of PHOMS and reliability of detection is unknown. In this multi-rater study, we demonstrate that the 2018 definition of PHOMS resulted in a poor multi-rater kappa of 0.356. We performed a Delphi consensus process to develop a consistent and refined definition of PHOMS with clear principles around the nature of PHOMS and how they differ from normal anatomy. Fifty explanatory teaching slides, provided as supplementary material, allowed our expert group of raters to achieve a good level of agreement (kappa 0.701, 50 OCT scans, 21 raters). We recommend adopting the refined definition for PHOMS.",

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AU - Petzold, Axel

AU - Biousse, Valerie

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AU - Katz, Bradley

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AU - Peragallo, Jason

AU - Sibony, Patrick

AU - Subramanian, Prem

AU - Rejdak, Robert

AU - Nowomiejska, Katarzyna

AU - Touitou, Valerie

AU - Warner, Judith

AU - Wegener, Marianne

AU - Wong, Sui

AU - Yu-Wai-Man, Patrick

AU - Hamann, Steffen

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N2 - Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are a new retinal optical coherence tomography (OCT) finding. The Optic Disc Drusen Studies Consortium had made recommendations to distinguish PHOMS from true optic disc drusen (ODD) in 2018. While publications on PHOMS have increased since then, the accuracy of the definition of PHOMS and reliability of detection is unknown. In this multi-rater study, we demonstrate that the 2018 definition of PHOMS resulted in a poor multi-rater kappa of 0.356. We performed a Delphi consensus process to develop a consistent and refined definition of PHOMS with clear principles around the nature of PHOMS and how they differ from normal anatomy. Fifty explanatory teaching slides, provided as supplementary material, allowed our expert group of raters to achieve a good level of agreement (kappa 0.701, 50 OCT scans, 21 raters). We recommend adopting the refined definition for PHOMS.

AB - Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are a new retinal optical coherence tomography (OCT) finding. The Optic Disc Drusen Studies Consortium had made recommendations to distinguish PHOMS from true optic disc drusen (ODD) in 2018. While publications on PHOMS have increased since then, the accuracy of the definition of PHOMS and reliability of detection is unknown. In this multi-rater study, we demonstrate that the 2018 definition of PHOMS resulted in a poor multi-rater kappa of 0.356. We performed a Delphi consensus process to develop a consistent and refined definition of PHOMS with clear principles around the nature of PHOMS and how they differ from normal anatomy. Fifty explanatory teaching slides, provided as supplementary material, allowed our expert group of raters to achieve a good level of agreement (kappa 0.701, 50 OCT scans, 21 raters). We recommend adopting the refined definition for PHOMS.

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Multirater Validation of Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS)

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Keywords

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