Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

Torben L Sørensen; Corinna Trebst; Pia Kivisäkk; Karen L Klaege; Amit Majmudar; Rivka Ravid; Hans Lassmann; David B Olsen; Robert M Strieter; Richard M Ransohoff; Finn Sellebjerg

doi:10.1016/s0165-5728(02)00097-8

Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

Torben L Sørensen, Corinna Trebst, Pia Kivisäkk, Karen L Klaege, Amit Majmudar, Rivka Ravid, Hans Lassmann, David B Olsen, Robert M Strieter, Richard M Ransohoff, Finn Sellebjerg

251 Citations (Scopus)

Abstract

T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.

Original language	English
Journal	Journal of Neuroimmunology
Volume	127
Issue number	1-2
Pages (from-to)	59-68
Number of pages	10
ISSN	0165-5728
DOIs	https://doi.org/10.1016/s0165-5728(02)00097-8
Publication status	Published - Jun 2002
Externally published	Yes

Keywords

Adult
Aged
Astrocytes/chemistry
CD4-Positive T-Lymphocytes/chemistry
CD8-Positive T-Lymphocytes/chemistry
Central Nervous System/chemistry
Cerebrospinal Fluid/cytology
Chemokine CXCL10
Chemokines, CXC/analysis
Female
Flow Cytometry
Humans
Male
Middle Aged
Multiple Sclerosis/immunology
Myelitis, Transverse/immunology
Optic Neuritis/immunology
Receptors, CXCR3
Receptors, Chemokine/analysis

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10.1016/s0165-5728(02)00097-8

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title = "Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system",

abstract = "T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.",

keywords = "Adult, Aged, Astrocytes/chemistry, CD4-Positive T-Lymphocytes/chemistry, CD8-Positive T-Lymphocytes/chemistry, Central Nervous System/chemistry, Cerebrospinal Fluid/cytology, Chemokine CXCL10, Chemokines, CXC/analysis, Female, Flow Cytometry, Humans, Male, Middle Aged, Multiple Sclerosis/immunology, Myelitis, Transverse/immunology, Optic Neuritis/immunology, Receptors, CXCR3, Receptors, Chemokine/analysis",

author = "S{\o}rensen, \{Torben L\} and Corinna Trebst and Pia Kivis{\"a}kk and Klaege, \{Karen L\} and Amit Majmudar and Rivka Ravid and Hans Lassmann and Olsen, \{David B\} and Strieter, \{Robert M\} and Ransohoff, \{Richard M\} and Finn Sellebjerg",

year = "2002",

month = jun,

doi = "10.1016/s0165-5728(02)00097-8",

language = "English",

volume = "127",

pages = "59--68",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier BV",

number = "1-2",

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TY - JOUR

T1 - Multiple sclerosis

T2 - a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

AU - Sørensen, Torben L

AU - Trebst, Corinna

AU - Kivisäkk, Pia

AU - Klaege, Karen L

AU - Majmudar, Amit

AU - Ravid, Rivka

AU - Lassmann, Hans

AU - Olsen, David B

AU - Strieter, Robert M

AU - Ransohoff, Richard M

AU - Sellebjerg, Finn

PY - 2002/6

Y1 - 2002/6

N2 - T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.

AB - T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.

KW - Adult

KW - Aged

KW - Astrocytes/chemistry

KW - CD4-Positive T-Lymphocytes/chemistry

KW - CD8-Positive T-Lymphocytes/chemistry

KW - Central Nervous System/chemistry

KW - Cerebrospinal Fluid/cytology

KW - Chemokine CXCL10

KW - Chemokines, CXC/analysis

KW - Female

KW - Flow Cytometry

KW - Humans

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis/immunology

KW - Myelitis, Transverse/immunology

KW - Optic Neuritis/immunology

KW - Receptors, CXCR3

KW - Receptors, Chemokine/analysis

UR - https://www.scopus.com/pages/publications/0036275625

U2 - 10.1016/s0165-5728(02)00097-8

DO - 10.1016/s0165-5728(02)00097-8

M3 - Journal article

C2 - 12044976

SN - 0165-5728

VL - 127

SP - 59

EP - 68

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

Abstract

Keywords

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