Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Multiple measures of HPA axis function in ultra high risk and first-episode schizophrenia patients

Research output: Contribution to journalJournal articleResearchpeer-review

  1. In utero exposure to maternal stressful life events and risk of polycystic ovary syndrome in the offspring: The Raine Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Familial associations in hair cortisol concentration: A cross-sectional analysis based on the Healthy Start study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Characteristics influencing expected cognitive performance during hypoglycaemia in type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Neuroticism modulates mood responses to pharmacological sex hormone manipulation in healthy women

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Associations between patterns in comorbid diagnostic trajectories of individuals with schizophrenia and etiological factors

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Pleiotropy between language impairment and broader behavioral disorders-an investigation of both common and rare genetic variants

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Digital Shared Decision-Making Interventions in Mental Healthcare: A Systematic Review and Meta-Analysis

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

INTRODUCTION: Abnormalities within hypothalamus-pituitary-adrenal (HPA) axis might interact with other neurobiological systems to enhance the risk of psychosis. Most of the neurodevelopmental and HPA axis changes occur in adolescence; this is also the period when prodromal and psychotic symptoms occur for the first time. More knowledge about how various stress components interact can advance understanding of the link between psychosis and the HPA axis.

METHOD: We examined 41 ultra high-risk (UHR) patients and 40 antipsychotic-naïve first-episode schizophrenia (FES) patients and compared them with 47 matched controls. The Perceived Stress Scale and the Recent Life Events Questionnaire were used to assess the stress levels. Day-time saliva samples were taken to measure cortisol. The pituitary gland volume was measured manually on the structural MRI using stereology.

RESULTS: Only the UHR patients, had a higher cortisol increase just after awakening (p = 0.009) compared to healthy controls. In UHR patients, we found a negative correlation between cortisol increase after awakening and symptom severity (p = 0.008). Pituitary gland volume and diurnal cortisol were not significantly different among the three groups. There was no correlation between pituitary gland volume, perceived stress/recent life events and any of the cortisol measures or symptoms.

CONCLUSION: Symptom severity during the very early phase of illness (UHR) seems to be associated with altered cortisol increase. Longitudinal studies in UHR patients would be useful to examine how stress levels affect the course of the illness.

Original languageEnglish
JournalPsychoneuroendocrinology
Volume92
Pages (from-to)72-80
Number of pages9
ISSN0306-4530
DOIs
Publication statusPublished - Jun 2018

ID: 54782992