Multiparametric flow cytometry profiling of neoplastic plasma cells in multiple myeloma

Hans E Johnsen; Martin Bøgsted; Tobias Wirenfeldt Klausen; Peter Gimsing; Alexander Schmitz; Erik Kjaersgaard; Tina Damgaard; Pia Voss; Lene M Knudsen; Anne K Mylin; Johan Lanng Nielsen; Bo Björkstrand; Astrid Gruber; Stig Lenhoff; Kari Remes; Inger Marie Dahl; Kirsten Fogd; Karen Dybkaer; Nordic Myeloma Study (NMSG)

doi:10.1002/cyto.b.20523

Multiparametric flow cytometry profiling of neoplastic plasma cells in multiple myeloma

Hans E Johnsen, Martin Bøgsted, Tobias Wirenfeldt Klausen, Peter Gimsing, Alexander Schmitz, Erik Kjaersgaard, Tina Damgaard, Pia Voss, Lene M Knudsen, Anne K Mylin, Johan Lanng Nielsen, Bo Björkstrand, Astrid Gruber, Stig Lenhoff, Kari Remes, Inger Marie Dahl, Kirsten Fogd, Karen Dybkaer, Nordic Myeloma Study (NMSG)

28 Citations (Scopus)

Abstract

The clinical impact of multiparametric flow cytometry (MFC) in multiple myeloma (MM) is still unclear and under evaluation. Further progress relies on multiparametric profiling of the neoplastic plasma cell (PC) compartment to provide an accurate image of the stage of differentiation. The primary aim of this study was to perform global analysis of CD expression on the PC compartment and subsequently to evaluate the prognostic impact. Secondary aims were to study the diagnostic and predictive impact.

Original language	English
Journal	Cytometry. Part B: Clinical Cytometry
Volume	78
Issue number	5
Pages (from-to)	338-47
Number of pages	10
ISSN	1552-4949
DOIs	https://doi.org/10.1002/cyto.b.20523
Publication status	Published - 1 Sep 2010

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Johnsen, H. E., Bøgsted, M., Klausen, T. W., Gimsing, P., Schmitz, A., Kjaersgaard, E., Damgaard, T., Voss, P., Knudsen, L. M., Mylin, A. K., Nielsen, J. L., Björkstrand, B., Gruber, A., Lenhoff, S., Remes, K., Dahl, I. M., Fogd, K., Dybkaer, K., & Nordic Myeloma Study (NMSG) (2010). Multiparametric flow cytometry profiling of neoplastic plasma cells in multiple myeloma. Cytometry. Part B: Clinical Cytometry, 78(5), 338-47. https://doi.org/10.1002/cyto.b.20523

Johnsen, HE, Bøgsted, M, Klausen, TW, Gimsing, P, Schmitz, A, Kjaersgaard, E, Damgaard, T, Voss, P, Knudsen, LM, Mylin, AK, Nielsen, JL, Björkstrand, B, Gruber, A, Lenhoff, S, Remes, K, Dahl, IM, Fogd, K, Dybkaer, K & Nordic Myeloma Study (NMSG) 2010, 'Multiparametric flow cytometry profiling of neoplastic plasma cells in multiple myeloma', Cytometry. Part B: Clinical Cytometry, vol. 78, no. 5, pp. 338-47. https://doi.org/10.1002/cyto.b.20523

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abstract = "The clinical impact of multiparametric flow cytometry (MFC) in multiple myeloma (MM) is still unclear and under evaluation. Further progress relies on multiparametric profiling of the neoplastic plasma cell (PC) compartment to provide an accurate image of the stage of differentiation. The primary aim of this study was to perform global analysis of CD expression on the PC compartment and subsequently to evaluate the prognostic impact. Secondary aims were to study the diagnostic and predictive impact.",

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AU - Klausen, Tobias Wirenfeldt

AU - Gimsing, Peter

AU - Schmitz, Alexander

AU - Kjaersgaard, Erik

AU - Damgaard, Tina

AU - Voss, Pia

AU - Knudsen, Lene M

AU - Mylin, Anne K

AU - Nielsen, Johan Lanng

AU - Björkstrand, Bo

AU - Gruber, Astrid

AU - Lenhoff, Stig

AU - Remes, Kari

AU - Dahl, Inger Marie

AU - Fogd, Kirsten

AU - Dybkaer, Karen

AU - Nordic Myeloma Study (NMSG)

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N2 - The clinical impact of multiparametric flow cytometry (MFC) in multiple myeloma (MM) is still unclear and under evaluation. Further progress relies on multiparametric profiling of the neoplastic plasma cell (PC) compartment to provide an accurate image of the stage of differentiation. The primary aim of this study was to perform global analysis of CD expression on the PC compartment and subsequently to evaluate the prognostic impact. Secondary aims were to study the diagnostic and predictive impact.

AB - The clinical impact of multiparametric flow cytometry (MFC) in multiple myeloma (MM) is still unclear and under evaluation. Further progress relies on multiparametric profiling of the neoplastic plasma cell (PC) compartment to provide an accurate image of the stage of differentiation. The primary aim of this study was to perform global analysis of CD expression on the PC compartment and subsequently to evaluate the prognostic impact. Secondary aims were to study the diagnostic and predictive impact.

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DO - 10.1002/cyto.b.20523

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JO - Cytometry Part B - Clinical Cytometry

JF - Cytometry Part B - Clinical Cytometry

SN - 1552-4949

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Multiparametric flow cytometry profiling of neoplastic plasma cells in multiple myeloma

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