Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Global and local envelope protein dynamics of hepatitis C virus determine broad antibody sensitivity

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. An alternate conformation of HCV E2 neutralizing face as an additional vaccine target

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Using structured progress to measure competence in flexible bronchoscopy

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Diagnostic imaging often outperforms the surgeon's ability to identify small structures during therapeutic procedures. Smart soft tissue markers that translate the sensitivity of diagnostic imaging into optimal therapeutic intervention are therefore highly warranted. This paper presents a unique adaptable liquid soft tissue marker system based on functionalized carbohydrates (Carbo-gel). The liquid state of these markers allows for high-precision placement under image guidance using thin needles. Based on step-by-step modifications, the image features and mechanical properties of markers can be optimized to bridge diagnostic imaging and specific therapeutic interventions. The performance of Carbo-gel is demonstrated for markers that (i) have radiographic, magnetic resonance, and ultrasound visibility; (ii) are palpable and visible; and (iii) are localizable by near-infrared fluorescence and radio guidance. The study demonstrates encouraging proof of concept for the liquid marker system as a well-tolerated multimodal imaging marker that can improve image-guided radiotherapy and surgical interventions, including robotic surgery.

Original languageEnglish
JournalScience Advances
Volume6
Issue number34
Pages (from-to)eabb5353
DOIs
Publication statusPublished - Aug 2020

ID: 61230188