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Multimodal analgesia versus traditional opiate based analgesia after cardiac surgery, a randomized controlled trial

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BACKGROUND: To evaluate if an opiate sparing multimodal regimen of dexamethasone, gabapentin, ibuprofen and paracetamol had better analgesic effect, less side effects and was safe compared to a traditional morphine and paracetamol regimen after cardiac surgery.

METHODS: Open-label, prospective randomized controlled trial. 180 patients undergoing cardiac procedures through median sternotomy, were included in the period march 2007-August 2009. 151 patients were available for analysis. Pain was assessed with the 11-numeric rating scale (11-NRS).

RESULTS: Patients in the multimodal group demonstrated significantly lower average pain scores from the day of surgery throughout the third postoperative day. Extensive nausea and vomiting, was found in no patient in the multimodal group but in 13 patients in the morphine group, p < 0.001. Postoperative rise in individual creatinine levels demonstrated a non-significant rise in the multimodal group, 33.0±53.4 vs. 19.9±48.5, p = 0.133. Patients in the multimodal group suffered less major in-hospital events in crude numbers: myocardial infarction (MI) (1 vs. 2, p = 0.54), stroke (0 vs. 3, p = 0.075), dialysis (1 vs. 2, p = 0.54), and gastrointestinal (GI) bleeding (0 vs. 1, p = 0.31). 30-day mortality was 1 vs. 2, p = 0.54.

CONCLUSIONS: In patients undergoing cardiac surgery, a multimodal regimen offered significantly better analgesia than a traditional opiate regimen. Nausea and vomiting complaints were significantly reduced. No safety issues were observed with the multimodal regimen.

TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT01966172.

Original languageEnglish
JournalJournal of Cardiothoracic Surgery
Volume9
Pages (from-to)52
ISSN1749-8090
DOIs
Publication statusPublished - 2014

    Research areas

  • Acetaminophen, Aged, Amines, Analgesia, Analgesics, Analgesics, Opioid, Cardiac Surgical Procedures, Cyclohexanecarboxylic Acids, Dexamethasone, Drug Therapy, Combination, Female, Humans, Ibuprofen, Male, Middle Aged, Pain Management, Pain, Postoperative, Prospective Studies, gamma-Aminobutyric Acid

ID: 45071455