Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017

David Terkelsen; Jacob Tolstrup; Camilla Hundahl Johnsen; Ole Lund; Helle Kiellberg Larsen; Peder Worning; Magnus Unemo; Henrik Westh

doi:10.2807/1560-7917.ES.2017.22.42.17-00659

Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017

David Terkelsen
, Jacob Tolstrup
, Camilla Hundahl Johnsen
, Ole Lund
, Helle Kiellberg Larsen
, Peder Worning
, Magnus Unemo
, Henrik Westh

87 Citations (Scopus)

Abstract

We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.

Original language	English
Journal	Eurosurveillance
Volume	22
Issue number	42
ISSN	1560-7917
DOIs	https://doi.org/10.2807/1560-7917.ES.2017.22.42.17-00659
Publication status	Published - Oct 2017

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Journal Article

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10.2807/1560-7917.ES.2017.22.42.17-00659

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title = "Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017",

abstract = "We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.",

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AU - Terkelsen, David

AU - Tolstrup, Jacob

AU - Johnsen, Camilla Hundahl

AU - Lund, Ole

AU - Larsen, Helle Kiellberg

AU - Worning, Peder

AU - Unemo, Magnus

AU - Westh, Henrik

PY - 2017/10

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N2 - We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.

AB - We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.

KW - Journal Article

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DO - 10.2807/1560-7917.ES.2017.22.42.17-00659

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JO - Eurosurveillance

JF - Eurosurveillance

IS - 42

ER -

Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017

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