Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017

David Terkelsen; Jacob Tolstrup; Camilla Hundahl Johnsen; Ole Lund; Helle Kiellberg Larsen; Peder Worning; Magnus Unemo; Henrik Westh

doi:10.2807/1560-7917.ES.2017.22.42.17-00659

Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017

David Terkelsen, Jacob Tolstrup, Camilla Hundahl Johnsen, Ole Lund, Helle Kiellberg Larsen, Peder Worning, Magnus Unemo, Henrik Westh

64 Citations (Scopus)

Abstract

We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.

Original language	English
Journal	Eurosurveillance
Volume	22
Issue number	42
ISSN	1560-7917
DOIs	https://doi.org/10.2807/1560-7917.ES.2017.22.42.17-00659
Publication status	Published - Oct 2017

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Journal Article

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10.2807/1560-7917.ES.2017.22.42.17-00659

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title = "Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017",

abstract = "We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.",

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AU - Terkelsen, David

AU - Tolstrup, Jacob

AU - Johnsen, Camilla Hundahl

AU - Lund, Ole

AU - Larsen, Helle Kiellberg

AU - Worning, Peder

AU - Unemo, Magnus

AU - Westh, Henrik

PY - 2017/10

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AB - We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.

KW - Journal Article

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JF - Eurosurveillance

SN - 1560-7917

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ER -

Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017

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