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Multidimensional Diffusion MRI Assists Myelin-sensitive Bound Pool Fraction in Differentiating Microstructural Maturity of Primate Brains

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Myelin-sensitive bound pool fraction (BPF) enables the tracking process of myelination in primate brains. The 3D BPF maps demonstrated rapid development of myelination from a 2-day-old brain to a 12-month-old brain and a slower increase from 12 months to 30 months. Even though the process of myelination is slow, multidimensional diffusion MRI indices are indeed helpful in significantly differentiating the microstructural maturity of primate brains. Our findings suggest that both indices, isotropic kurtosis (MKI, associated with cell density variance) and microscopic anisotropy (MKA, correlated with cell eccentricity) are significant imaging markers for microstructural differentiation in the development of primate brains.
Original languageEnglish
Title of host publicationProceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition
Number of pages3
PublisherThe International Society for Magnetic Resonance in Medicine
Publication date2020
Pages1-3
Article number861
Publication statusPublished - 2020
EventISMRM & SMRT Virtual Conference & Exhibition 2020 - Virtual conference
Duration: 8 Aug 202014 Aug 2020
https://www.ismrm.org/20m/

Conference

ConferenceISMRM & SMRT Virtual Conference & Exhibition 2020
LocationVirtual conference
Periode08/08/202014/08/2020
Internetadresse

Event

ISMRM & SMRT Virtual Conference & Exhibition 2020

08/08/202014/08/2020

Event: Conference

ID: 62024380