Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Multichannel anodal tDCS over the left dorsolateral prefrontal cortex in a paediatric population

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Evaluation of 2D super-resolution ultrasound imaging of the rat renal vasculature using ex vivo micro-computed tomography

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Automatic airway segmentation from computed tomography using robust and efficient 3-D convolutional neural networks

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Cardiac hypoxic resistance and decreasing lactate during maximum apnea in elite breath hold divers

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Can topical application of numbing cream improve the efficacy of sham TDCS?

    Research output: Contribution to conferencePosterResearch

  2. Detection of biological signals from a live mammalian muscle using an early stage diamond quantum sensor

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Efficient high-resolution TMS mapping of the human motor cortex by nonlinear regression

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Sensitivity and resolution improvement for in vivo magnetic resonance current-density imaging of the human brain

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. New tools for computational modeling of non-invasive brain stimulation in SimNIBS

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Maike Splittgerber
  • Christoph Borzikowsky
  • Ricardo Salvador
  • Oula Puonti
  • Kiriaki Papadimitriou
  • Christoph Merschformann
  • Maria Chiara Biagi
  • Tristan Stenner
  • Hannah Brauer
  • Carolin Breitling-Ziegler
  • Alexander Prehn-Kristensen
  • Kerstin Krauel
  • Giulio Ruffini
  • Anya Pedersen
  • Frauke Nees
  • Axel Thielscher
  • Astrid Dempfle
  • Michael Siniatchkin
  • Vera Moliadze
View graph of relations

Methodological studies investigating transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (lDLPFC) in paediatric populations are limited. Therefore, we investigated in a paediatric population whether stimulation success of multichannel tDCS over the lDLPFC depends on concurrent task performance and individual head anatomy. In a randomised, sham-controlled, double-blind crossover study 22 healthy participants (10-17 years) received 2 mA multichannel anodal tDCS (atDCS) over the lDLPFC with and without a 2-back working memory (WM) task. After stimulation, the 2-back task and a Flanker task were performed. Resting state and task-related EEG were recorded. In 16 participants we calculated the individual electric field (E-field) distribution. Performance and neurophysiological activity in the 2-back task were not affected by atDCS. atDCS reduced reaction times in the Flanker task, independent of whether atDCS had been combined with the 2-back task. Flanker task related beta oscillation increased following stimulation without 2-back task performance. atDCS effects were not correlated with the E-field. We found no effect of multichannel atDCS over the lDLPFC on WM in children/adolescents but a transfer effect on interference control. While this effect on behaviour was independent of concurrent task performance, neurophysiological activity might be more sensitive to cognitive activation during stimulation. However, our results are limited by the small sample size, the lack of an active control group and variations in WM performance.

Original languageEnglish
Article number21512
JournalScientific Reports
Volume11
Issue number1
Pages (from-to)1-15
Number of pages15
ISSN2045-2322
DOIs
Publication statusPublished - 2 Nov 2021

Bibliographical note

© 2021. The Author(s).

ID: 69022632