Multi-modal and multi-scale clinical retinal imaging system with pupil and retinal tracking

Muhammad Faizan Shirazi; Jordi Andilla; Nicolas Lefaudeux; Claudia Valdes; Florian Schwarzhans; Marine Durand; Konstantinos Ntatsis; Danilo Andrade De Jesus; Luisa Sanchez Brea; Kiyoko Gocho; Josselin Gautier; Christina Eckmann-Hansen; Marie Elise Wistrup Torm; Abdullah Amini; Stefan Klein; Theo Van Walsum; Kate Grieve; Michel Paques; Michael Larsen; Pablo Loza-Alvarez; Xavier Levecq; Nicolas Chateau; Michael Pircher

doi:10.1038/s41598-022-13631-1

Multi-modal and multi-scale clinical retinal imaging system with pupil and retinal tracking

Muhammad Faizan Shirazi, Jordi Andilla, Nicolas Lefaudeux, Claudia Valdes, Florian Schwarzhans, Marine Durand, Konstantinos Ntatsis, Danilo Andrade De Jesus, Luisa Sanchez Brea, Kiyoko Gocho, Josselin Gautier, Christina Eckmann-Hansen, Marie Elise Wistrup Torm, Abdullah Amini, Stefan Klein, Theo Van Walsum, Kate Grieve, Michel Paques, Michael Larsen, Pablo Loza-AlvarezXavier Levecq, Nicolas Chateau, Michael Pircher^*

^*Corresponding author for this work

Department of Ophthalmology

Abstract

We present a compact multi-modal and multi-scale retinal imaging instrument with an angiographic functional extension for clinical use. The system integrates scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT) and OCT angiography (OCTA) imaging modalities and provides multi-scale fields of view. For high resolution, and high lateral resolution in particular, cellular imaging correction of aberrations by adaptive optics (AO) is employed. The entire instrument has a compact design and the scanning head is mounted on motorized translation stages that enable 3D self-alignment with respect to the subject's eye by tracking the pupil position. Retinal tracking, based on the information provided by SLO, is incorporated in the instrument to compensate for retinal motion during OCT imaging. The imaging capabilities of the multi-modal and multi-scale instrument were tested by imaging healthy volunteers and patients.

Original language	English
Article number	9577
Journal	Scientific Reports
Volume	12
Issue number	1
ISSN	2045-2322
DOIs	https://doi.org/10.1038/s41598-022-13631-1
Publication status	Published - 10 Jun 2022

Keywords

Humans
Ophthalmoscopy/methods
Optics and Photonics
Pupil
Retina/diagnostic imaging
Tomography, Optical Coherence/methods

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10.1038/s41598-022-13631-1

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Shirazi, M. F., Andilla, J., Lefaudeux, N., Valdes, C., Schwarzhans, F., Durand, M., Ntatsis, K., De Jesus, D. A., Sanchez Brea, L., Gocho, K., Gautier, J., Eckmann-Hansen, C., Torm, M. E. W., Amini, A., Klein, S., Van Walsum, T., Grieve, K., Paques, M., Larsen, M., ... Pircher, M. (2022). Multi-modal and multi-scale clinical retinal imaging system with pupil and retinal tracking. Scientific Reports, 12(1), Article 9577. https://doi.org/10.1038/s41598-022-13631-1

Shirazi, MF, Andilla, J, Lefaudeux, N, Valdes, C, Schwarzhans, F, Durand, M, Ntatsis, K, De Jesus, DA, Sanchez Brea, L, Gocho, K, Gautier, J, Eckmann-Hansen, C, Torm, MEW , Amini, A, Klein, S, Van Walsum, T, Grieve, K, Paques, M, Larsen, M, Loza-Alvarez, P, Levecq, X, Chateau, N & Pircher, M 2022, 'Multi-modal and multi-scale clinical retinal imaging system with pupil and retinal tracking', Scientific Reports, vol. 12, no. 1, 9577. https://doi.org/10.1038/s41598-022-13631-1

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abstract = "We present a compact multi-modal and multi-scale retinal imaging instrument with an angiographic functional extension for clinical use. The system integrates scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT) and OCT angiography (OCTA) imaging modalities and provides multi-scale fields of view. For high resolution, and high lateral resolution in particular, cellular imaging correction of aberrations by adaptive optics (AO) is employed. The entire instrument has a compact design and the scanning head is mounted on motorized translation stages that enable 3D self-alignment with respect to the subject's eye by tracking the pupil position. Retinal tracking, based on the information provided by SLO, is incorporated in the instrument to compensate for retinal motion during OCT imaging. The imaging capabilities of the multi-modal and multi-scale instrument were tested by imaging healthy volunteers and patients.",

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AU - Shirazi, Muhammad Faizan

AU - Andilla, Jordi

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AU - Valdes, Claudia

AU - Schwarzhans, Florian

AU - Durand, Marine

AU - Ntatsis, Konstantinos

AU - De Jesus, Danilo Andrade

AU - Sanchez Brea, Luisa

AU - Gocho, Kiyoko

AU - Gautier, Josselin

AU - Eckmann-Hansen, Christina

AU - Torm, Marie Elise Wistrup

AU - Amini, Abdullah

AU - Klein, Stefan

AU - Van Walsum, Theo

AU - Grieve, Kate

AU - Paques, Michel

AU - Larsen, Michael

AU - Loza-Alvarez, Pablo

AU - Levecq, Xavier

AU - Chateau, Nicolas

AU - Pircher, Michael

PY - 2022/6/10

Y1 - 2022/6/10

N2 - We present a compact multi-modal and multi-scale retinal imaging instrument with an angiographic functional extension for clinical use. The system integrates scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT) and OCT angiography (OCTA) imaging modalities and provides multi-scale fields of view. For high resolution, and high lateral resolution in particular, cellular imaging correction of aberrations by adaptive optics (AO) is employed. The entire instrument has a compact design and the scanning head is mounted on motorized translation stages that enable 3D self-alignment with respect to the subject's eye by tracking the pupil position. Retinal tracking, based on the information provided by SLO, is incorporated in the instrument to compensate for retinal motion during OCT imaging. The imaging capabilities of the multi-modal and multi-scale instrument were tested by imaging healthy volunteers and patients.

AB - We present a compact multi-modal and multi-scale retinal imaging instrument with an angiographic functional extension for clinical use. The system integrates scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT) and OCT angiography (OCTA) imaging modalities and provides multi-scale fields of view. For high resolution, and high lateral resolution in particular, cellular imaging correction of aberrations by adaptive optics (AO) is employed. The entire instrument has a compact design and the scanning head is mounted on motorized translation stages that enable 3D self-alignment with respect to the subject's eye by tracking the pupil position. Retinal tracking, based on the information provided by SLO, is incorporated in the instrument to compensate for retinal motion during OCT imaging. The imaging capabilities of the multi-modal and multi-scale instrument were tested by imaging healthy volunteers and patients.

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KW - Ophthalmoscopy/methods

KW - Optics and Photonics

KW - Pupil

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KW - Tomography, Optical Coherence/methods

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VL - 12

JO - Scientific Reports

JF - Scientific Reports

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M1 - 9577

ER -

Multi-modal and multi-scale clinical retinal imaging system with pupil and retinal tracking

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Keywords

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