Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Mucosal malignant melanoma - a clinical, oncological, pathological and genetic survey

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Primary antibiotic resistance of Helicobacter pylori strains among adults and children in a tertiary referral centre in Lithuania

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. A short history of microbial biofilms and biofilm infections

    Research output: Contribution to journalReviewResearchpeer-review

  3. Biofilms and host response - helpful or harmful

    Research output: Contribution to journalReviewResearchpeer-review

  4. Diagnosis of biofilm infections in cystic fibrosis patients

    Research output: Contribution to journalReviewResearchpeer-review

  1. Development of depression in patients with oral cavity cancer: a systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  2. Management of Ocular Manifestations of Atopic Dermatitis: A Consensus Meeting Using a Modified Delphi Process

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Chronic rhinosinusitis in COPD: A prevalent but unrecognized comorbidity impacting health related quality of life

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Face masks for the prevention of COVID-19 - Rationale and design of the randomised controlled trial DANMASK-19

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Association between head and neck cancer and sexually transmitted diseases: a Danish nationwide, case-control study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Mucosal melanomas constitute 1.3% of all melanomas and they may develop in any mucosal membrane. Conjunctival melanomas (0.5/million/year) and melanomas in the sinonasal cavity (0.5/million/year) are the most common, followed by anorectal melanomas (0.4/million/year) and melanomas in the oral cavity (0.2/million/year). Anorectal melanoma occurs slightly more often in females, whereas oral melanoma has a male predilection. Mucosal melanoma most commonly develops in a patient's sixth or seventh decade of life, and no differences between races have been found except for sinonasal melanoma and conjunctival melanoma, which are very rare in Black people. The symptoms are not tumour-specific and are related to the organ system affected, and the disease is most often diagnosed at an advanced clinical stage. The diagnosis of a primary tumour is difficult, and metastatic cutaneous melanoma and choroidal melanoma must be excluded. Mutations in KIT are frequently found, while BRAF and NRAS mutations are rarely found - except in conjunctival melanomas that carry BRAF mutations. Mutations in the TERT promotor region are also found in mucosal melanomas. Complete surgical resection with free margins is the treatment of choice. The prognosis is poor, with the 5-year survival rate ranging from 0% (gastric melanoma) to 80% (conjunctival melanoma).

Original languageEnglish
JournalAPMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Volume124
Issue number6
Pages (from-to)475-86
Number of pages12
ISSN0903-4641
DOIs
Publication statusPublished - Jun 2016

    Research areas

  • Journal Article

ID: 49633105