MTHFR C677T genotype and cardiovascular risk in a general population without mandatory folic acid fortification

Lise Lotte N Husemoen; Tea Skaaby; Torben Jørgensen; Betina H Thuesen; Mogens Fenger; Niels Grarup; Camilla Helene Sandholt; Torben Hansen; Oluf Borbye Pedersen; Allan Linneberg

doi:10.1007/s00394-014-0659-2

MTHFR C677T genotype and cardiovascular risk in a general population without mandatory folic acid fortification

Lise Lotte N Husemoen, Tea Skaaby, Torben Jørgensen, Betina H Thuesen, Mogens Fenger, Niels Grarup, Camilla Helene Sandholt, Torben Hansen, Oluf Borbye Pedersen, Allan Linneberg

32 Citations (Scopus)

Abstract

Meta-analyses have suggested an effect of MTHFR C677T genotype (rs1801133), a proxy for blood total homocysteine, on cardiovascular disease (CVD) in populations with low population dietary folate. The aim was to examine the association and effect modification by serum folate and vitamin B12 levels between MTHFR and CVD-related outcomes in a general population with no mandatory folic acid fortification policy.

Original language	English
Journal	European Journal of Nutrition
Volume	53
Issue number	7
Pages (from-to)	1549-59
ISSN	1436-6207
DOIs	https://doi.org/10.1007/s00394-014-0659-2
Publication status	Published - 24 Jan 2014

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abstract = "Meta-analyses have suggested an effect of MTHFR C677T genotype (rs1801133), a proxy for blood total homocysteine, on cardiovascular disease (CVD) in populations with low population dietary folate. The aim was to examine the association and effect modification by serum folate and vitamin B12 levels between MTHFR and CVD-related outcomes in a general population with no mandatory folic acid fortification policy.",

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AU - Husemoen, Lise Lotte N

AU - Skaaby, Tea

AU - Jørgensen, Torben

AU - Thuesen, Betina H

AU - Fenger, Mogens

AU - Grarup, Niels

AU - Sandholt, Camilla Helene

AU - Hansen, Torben

AU - Pedersen, Oluf Borbye

AU - Linneberg, Allan

PY - 2014/1/24

Y1 - 2014/1/24

N2 - Meta-analyses have suggested an effect of MTHFR C677T genotype (rs1801133), a proxy for blood total homocysteine, on cardiovascular disease (CVD) in populations with low population dietary folate. The aim was to examine the association and effect modification by serum folate and vitamin B12 levels between MTHFR and CVD-related outcomes in a general population with no mandatory folic acid fortification policy.

AB - Meta-analyses have suggested an effect of MTHFR C677T genotype (rs1801133), a proxy for blood total homocysteine, on cardiovascular disease (CVD) in populations with low population dietary folate. The aim was to examine the association and effect modification by serum folate and vitamin B12 levels between MTHFR and CVD-related outcomes in a general population with no mandatory folic acid fortification policy.

UR - https://www.scopus.com/pages/publications/84918792776

U2 - 10.1007/s00394-014-0659-2

DO - 10.1007/s00394-014-0659-2

M3 - Journal article

C2 - 24458267

SN - 1436-6207

VL - 53

SP - 1549

EP - 1559

JO - European Journal of Nutrition

JF - European Journal of Nutrition

IS - 7

ER -

MTHFR C677T genotype and cardiovascular risk in a general population without mandatory folic acid fortification

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