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MRI lesions in the sacroiliac joints of patients with spondyloarthritis: an update of definitions and validation by the ASAS MRI working group

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Maksymowych, WP, Lambert, RG, Østergaard, M, Pedersen, SJ, Machado, PM, Weber, U, Bennett, AN, Braun, J, Burgos-Vargas, R, de Hooge, M, Deodhar, AA, Eshed, I, Jurik, AG, Hermann, K-GA, Landewé, RB, Marzo-Ortega, H, Navarro-Compán, V, Poddubnyy, D, Reijnierse, M, Rudwaleit, M, Sieper, J, Van den Bosch, FE, van der Heijde, D, van der Horst-Bruinsma, IE, Wichuk, S & Baraliakos, X 2019, 'MRI lesions in the sacroiliac joints of patients with spondyloarthritis: an update of definitions and validation by the ASAS MRI working group' Annals of the Rheumatic Diseases, vol. 78, no. 11, pp. 1550-1558. https://doi.org/10.1136/annrheumdis-2019-215589

APA

CBE

Maksymowych WP, Lambert RG, Østergaard M, Pedersen SJ, Machado PM, Weber U, Bennett AN, Braun J, Burgos-Vargas R, de Hooge M, Deodhar AA, Eshed I, Jurik AG, Hermann K-GA, Landewé RB, Marzo-Ortega H, Navarro-Compán V, Poddubnyy D, Reijnierse M, Rudwaleit M, Sieper J, Van den Bosch FE, van der Heijde D, van der Horst-Bruinsma IE, Wichuk S, Baraliakos X. 2019. MRI lesions in the sacroiliac joints of patients with spondyloarthritis: an update of definitions and validation by the ASAS MRI working group. Annals of the Rheumatic Diseases. 78(11):1550-1558. https://doi.org/10.1136/annrheumdis-2019-215589

MLA

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Author

Maksymowych, Walter P ; Lambert, Robert Gw ; Østergaard, Mikkel ; Pedersen, Susanne Juhl ; Machado, Pedro M ; Weber, Ulrich ; Bennett, Alexander N ; Braun, Juergen ; Burgos-Vargas, Ruben ; de Hooge, Manouk ; Deodhar, Atul A ; Eshed, Iris ; Jurik, Anne Grethe ; Hermann, Kay-Geert Armin ; Landewé, Robert Bm ; Marzo-Ortega, Helena ; Navarro-Compán, Victoria ; Poddubnyy, Denis ; Reijnierse, Monique ; Rudwaleit, Martin ; Sieper, Joachim ; Van den Bosch, Filip E ; van der Heijde, Désirée ; van der Horst-Bruinsma, Irene E ; Wichuk, Stephanie ; Baraliakos, Xenofon. / MRI lesions in the sacroiliac joints of patients with spondyloarthritis : an update of definitions and validation by the ASAS MRI working group. In: Annals of the Rheumatic Diseases. 2019 ; Vol. 78, No. 11. pp. 1550-1558.

Bibtex

@article{dae66e3af9714c008090a494cf8dc63b,
title = "MRI lesions in the sacroiliac joints of patients with spondyloarthritis: an update of definitions and validation by the ASAS MRI working group",
abstract = "OBJECTIVES: The Assessment of SpondyloArthritis international Society (ASAS) MRI working group (WG) was convened to generate a consensus update on standardised definitions for MRI lesions in the sacroiliac joint (SIJ) of patients with spondyloarthritis (SpA), and to conduct preliminary validation.METHODS: The literature pertaining to these MRI lesion definitions was discussed at three meetings of the group. 25 investigators (20 rheumatologists, 5 radiologists) determined which definitions should be retained or required revision, and which required a new definition. Lesion definitions were assessed in a multi-reader validation exercise using 278 MRI scans from the ASAS classification cohort by global assessment (lesion present/absent) and detailed scoring (inflammation and structural). Reliability of detection of lesions was analysed using kappa statistics and the intraclass correlation coefficient (ICC).RESULTS: No revisions were made to the current ASAS definition of a positive SIJ MRI or definitions for subchondral inflammation and sclerosis. The following definitions were revised: capsulitis, enthesitis, fat lesion and erosion. New definitions were developed for joint space enhancement, joint space fluid, fat metaplasia in an erosion cavity, ankylosis and bone bud. The most frequently detected structural lesion, erosion, was detected almost as reliably as subchondral inflammation (κappa/ICC:0.61/0.54 and 0.60/0.83) . Fat metaplasia in an erosion cavity and ankylosis were also reliably detected despite their low frequency (κappa/ICC:0.50/0.37 and 0.58/0.97).CONCLUSION: The ASAS-MRI WG concluded that several definitions required revision and some new definitions were necessary. Multi-reader validation demonstrated substantial reliability for the most frequently detected lesions and comparable reliability between active and structural lesions.",
author = "Maksymowych, {Walter P} and Lambert, {Robert Gw} and Mikkel {\O}stergaard and Pedersen, {Susanne Juhl} and Machado, {Pedro M} and Ulrich Weber and Bennett, {Alexander N} and Juergen Braun and Ruben Burgos-Vargas and {de Hooge}, Manouk and Deodhar, {Atul A} and Iris Eshed and Jurik, {Anne Grethe} and Hermann, {Kay-Geert Armin} and Landew{\'e}, {Robert Bm} and Helena Marzo-Ortega and Victoria Navarro-Comp{\'a}n and Denis Poddubnyy and Monique Reijnierse and Martin Rudwaleit and Joachim Sieper and {Van den Bosch}, {Filip E} and {van der Heijde}, D{\'e}sir{\'e}e and {van der Horst-Bruinsma}, {Irene E} and Stephanie Wichuk and Xenofon Baraliakos",
note = "COPECARE",
year = "2019",
month = "11",
doi = "10.1136/annrheumdis-2019-215589",
language = "English",
volume = "78",
pages = "1550--1558",
journal = "Annals of the Rheumatic Diseases",
issn = "0003-4967",
publisher = "B M J Group",
number = "11",

}

RIS

TY - JOUR

T1 - MRI lesions in the sacroiliac joints of patients with spondyloarthritis

T2 - an update of definitions and validation by the ASAS MRI working group

AU - Maksymowych, Walter P

AU - Lambert, Robert Gw

AU - Østergaard, Mikkel

AU - Pedersen, Susanne Juhl

AU - Machado, Pedro M

AU - Weber, Ulrich

AU - Bennett, Alexander N

AU - Braun, Juergen

AU - Burgos-Vargas, Ruben

AU - de Hooge, Manouk

AU - Deodhar, Atul A

AU - Eshed, Iris

AU - Jurik, Anne Grethe

AU - Hermann, Kay-Geert Armin

AU - Landewé, Robert Bm

AU - Marzo-Ortega, Helena

AU - Navarro-Compán, Victoria

AU - Poddubnyy, Denis

AU - Reijnierse, Monique

AU - Rudwaleit, Martin

AU - Sieper, Joachim

AU - Van den Bosch, Filip E

AU - van der Heijde, Désirée

AU - van der Horst-Bruinsma, Irene E

AU - Wichuk, Stephanie

AU - Baraliakos, Xenofon

N1 - COPECARE

PY - 2019/11

Y1 - 2019/11

N2 - OBJECTIVES: The Assessment of SpondyloArthritis international Society (ASAS) MRI working group (WG) was convened to generate a consensus update on standardised definitions for MRI lesions in the sacroiliac joint (SIJ) of patients with spondyloarthritis (SpA), and to conduct preliminary validation.METHODS: The literature pertaining to these MRI lesion definitions was discussed at three meetings of the group. 25 investigators (20 rheumatologists, 5 radiologists) determined which definitions should be retained or required revision, and which required a new definition. Lesion definitions were assessed in a multi-reader validation exercise using 278 MRI scans from the ASAS classification cohort by global assessment (lesion present/absent) and detailed scoring (inflammation and structural). Reliability of detection of lesions was analysed using kappa statistics and the intraclass correlation coefficient (ICC).RESULTS: No revisions were made to the current ASAS definition of a positive SIJ MRI or definitions for subchondral inflammation and sclerosis. The following definitions were revised: capsulitis, enthesitis, fat lesion and erosion. New definitions were developed for joint space enhancement, joint space fluid, fat metaplasia in an erosion cavity, ankylosis and bone bud. The most frequently detected structural lesion, erosion, was detected almost as reliably as subchondral inflammation (κappa/ICC:0.61/0.54 and 0.60/0.83) . Fat metaplasia in an erosion cavity and ankylosis were also reliably detected despite their low frequency (κappa/ICC:0.50/0.37 and 0.58/0.97).CONCLUSION: The ASAS-MRI WG concluded that several definitions required revision and some new definitions were necessary. Multi-reader validation demonstrated substantial reliability for the most frequently detected lesions and comparable reliability between active and structural lesions.

AB - OBJECTIVES: The Assessment of SpondyloArthritis international Society (ASAS) MRI working group (WG) was convened to generate a consensus update on standardised definitions for MRI lesions in the sacroiliac joint (SIJ) of patients with spondyloarthritis (SpA), and to conduct preliminary validation.METHODS: The literature pertaining to these MRI lesion definitions was discussed at three meetings of the group. 25 investigators (20 rheumatologists, 5 radiologists) determined which definitions should be retained or required revision, and which required a new definition. Lesion definitions were assessed in a multi-reader validation exercise using 278 MRI scans from the ASAS classification cohort by global assessment (lesion present/absent) and detailed scoring (inflammation and structural). Reliability of detection of lesions was analysed using kappa statistics and the intraclass correlation coefficient (ICC).RESULTS: No revisions were made to the current ASAS definition of a positive SIJ MRI or definitions for subchondral inflammation and sclerosis. The following definitions were revised: capsulitis, enthesitis, fat lesion and erosion. New definitions were developed for joint space enhancement, joint space fluid, fat metaplasia in an erosion cavity, ankylosis and bone bud. The most frequently detected structural lesion, erosion, was detected almost as reliably as subchondral inflammation (κappa/ICC:0.61/0.54 and 0.60/0.83) . Fat metaplasia in an erosion cavity and ankylosis were also reliably detected despite their low frequency (κappa/ICC:0.50/0.37 and 0.58/0.97).CONCLUSION: The ASAS-MRI WG concluded that several definitions required revision and some new definitions were necessary. Multi-reader validation demonstrated substantial reliability for the most frequently detected lesions and comparable reliability between active and structural lesions.

U2 - 10.1136/annrheumdis-2019-215589

DO - 10.1136/annrheumdis-2019-215589

M3 - Journal article

VL - 78

SP - 1550

EP - 1558

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

IS - 11

ER -

ID: 58908867