Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Mother-child transmission of epigenetic information by tunable polymorphic imprinting

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Carpenter, BL, Zhou, W, Madaj, Z, DeWitt, AK, Ross, JP, Grønbæk, K, Liang, G, Clark, SJ, Molloy, PL & Jones, PA 2018, 'Mother-child transmission of epigenetic information by tunable polymorphic imprinting' Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 51, pp. E11970-E11977. https://doi.org/10.1073/pnas.1815005115

APA

CBE

MLA

Vancouver

Author

Carpenter, Brittany L ; Zhou, Wanding ; Madaj, Zachary ; DeWitt, Ashley K ; Ross, Jason P ; Grønbæk, Kirsten ; Liang, Gangning ; Clark, Susan J ; Molloy, Peter L ; Jones, Peter A. / Mother-child transmission of epigenetic information by tunable polymorphic imprinting. In: Proceedings of the National Academy of Sciences of the United States of America. 2018 ; Vol. 115, No. 51. pp. E11970-E11977.

Bibtex

@article{b02b059a41e64eb1adbaa94d0314078f,
title = "Mother-child transmission of epigenetic information by tunable polymorphic imprinting",
abstract = "Genomic imprinting mediated by DNA methylation restricts gene expression to a single allele determined by parental origin and is not generally considered to be under genetic or environmental influence. Here, we focused on a differentially methylated region (DMR) of approximately 1.9 kb that includes a 101-bp noncoding RNA gene (nc886/VTRNA2-1), which is maternally imprinted in ∼75{\%} of humans. This is unlike other imprinted genes, which demonstrate monoallelic methylation in 100{\%} of individuals. The DMR includes a CTCF binding site on the centromeric side defining the DMR boundary and is flanked by a CTCF binding site on the telomeric side. The centromeric CTCF binding site contains an A/C polymorphism (rs2346018); the C allele is associated with less imprinting. The frequency of imprinting of the nc886 DMR in infants was linked to at least two nongenetic factors, maternal age at delivery and season of conception. In a separate cohort, nc886 imprinting was associated with lower body mass index in children at 5 y of age. Thus, we propose that the imprinting status of the nc886 DMR is {"}tunable{"} in that it is associated with maternal haplotype and prenatal environment. This provides a potential mechanism for transmitting information, with phenotypic consequences, from mother to child.",
author = "Carpenter, {Brittany L} and Wanding Zhou and Zachary Madaj and DeWitt, {Ashley K} and Ross, {Jason P} and Kirsten Gr{\o}nb{\ae}k and Gangning Liang and Clark, {Susan J} and Molloy, {Peter L} and Jones, {Peter A}",
note = "Copyright {\circledC} 2018 the Author(s). Published by PNAS.",
year = "2018",
month = "12",
day = "18",
doi = "10.1073/pnas.1815005115",
language = "English",
volume = "115",
pages = "E11970--E11977",
journal = "National Academy of Sciences. Proceedings",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "51",

}

RIS

TY - JOUR

T1 - Mother-child transmission of epigenetic information by tunable polymorphic imprinting

AU - Carpenter, Brittany L

AU - Zhou, Wanding

AU - Madaj, Zachary

AU - DeWitt, Ashley K

AU - Ross, Jason P

AU - Grønbæk, Kirsten

AU - Liang, Gangning

AU - Clark, Susan J

AU - Molloy, Peter L

AU - Jones, Peter A

N1 - Copyright © 2018 the Author(s). Published by PNAS.

PY - 2018/12/18

Y1 - 2018/12/18

N2 - Genomic imprinting mediated by DNA methylation restricts gene expression to a single allele determined by parental origin and is not generally considered to be under genetic or environmental influence. Here, we focused on a differentially methylated region (DMR) of approximately 1.9 kb that includes a 101-bp noncoding RNA gene (nc886/VTRNA2-1), which is maternally imprinted in ∼75% of humans. This is unlike other imprinted genes, which demonstrate monoallelic methylation in 100% of individuals. The DMR includes a CTCF binding site on the centromeric side defining the DMR boundary and is flanked by a CTCF binding site on the telomeric side. The centromeric CTCF binding site contains an A/C polymorphism (rs2346018); the C allele is associated with less imprinting. The frequency of imprinting of the nc886 DMR in infants was linked to at least two nongenetic factors, maternal age at delivery and season of conception. In a separate cohort, nc886 imprinting was associated with lower body mass index in children at 5 y of age. Thus, we propose that the imprinting status of the nc886 DMR is "tunable" in that it is associated with maternal haplotype and prenatal environment. This provides a potential mechanism for transmitting information, with phenotypic consequences, from mother to child.

AB - Genomic imprinting mediated by DNA methylation restricts gene expression to a single allele determined by parental origin and is not generally considered to be under genetic or environmental influence. Here, we focused on a differentially methylated region (DMR) of approximately 1.9 kb that includes a 101-bp noncoding RNA gene (nc886/VTRNA2-1), which is maternally imprinted in ∼75% of humans. This is unlike other imprinted genes, which demonstrate monoallelic methylation in 100% of individuals. The DMR includes a CTCF binding site on the centromeric side defining the DMR boundary and is flanked by a CTCF binding site on the telomeric side. The centromeric CTCF binding site contains an A/C polymorphism (rs2346018); the C allele is associated with less imprinting. The frequency of imprinting of the nc886 DMR in infants was linked to at least two nongenetic factors, maternal age at delivery and season of conception. In a separate cohort, nc886 imprinting was associated with lower body mass index in children at 5 y of age. Thus, we propose that the imprinting status of the nc886 DMR is "tunable" in that it is associated with maternal haplotype and prenatal environment. This provides a potential mechanism for transmitting information, with phenotypic consequences, from mother to child.

U2 - 10.1073/pnas.1815005115

DO - 10.1073/pnas.1815005115

M3 - Journal article

VL - 115

SP - E11970-E11977

JO - National Academy of Sciences. Proceedings

JF - National Academy of Sciences. Proceedings

SN - 0027-8424

IS - 51

ER -

ID: 56422660