Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Mother-child transmission of epigenetic information by tunable polymorphic imprinting

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Hypervariable region 1 and N-linked glycans of hepatitis C regulate virion neutralization by modulating envelope conformations

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Lipoprotein lipase is active as a monomer

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Paternal comeback in mitochondrial DNA inheritance

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Epigenetic therapy in hematological cancers

    Research output: Contribution to journalReviewResearchpeer-review

  2. Enzyme-free digital counting of endogenous circular RNA molecules in B-cell malignancies

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Epidemiology of chronic red-cell transfusion recipients in Sweden and Denmark-a 10 year follow-up study

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Brittany L Carpenter
  • Wanding Zhou
  • Zachary Madaj
  • Ashley K DeWitt
  • Jason P Ross
  • Kirsten Grønbæk
  • Gangning Liang
  • Susan J Clark
  • Peter L Molloy
  • Peter A Jones
View graph of relations

Genomic imprinting mediated by DNA methylation restricts gene expression to a single allele determined by parental origin and is not generally considered to be under genetic or environmental influence. Here, we focused on a differentially methylated region (DMR) of approximately 1.9 kb that includes a 101-bp noncoding RNA gene (nc886/VTRNA2-1), which is maternally imprinted in ∼75% of humans. This is unlike other imprinted genes, which demonstrate monoallelic methylation in 100% of individuals. The DMR includes a CTCF binding site on the centromeric side defining the DMR boundary and is flanked by a CTCF binding site on the telomeric side. The centromeric CTCF binding site contains an A/C polymorphism (rs2346018); the C allele is associated with less imprinting. The frequency of imprinting of the nc886 DMR in infants was linked to at least two nongenetic factors, maternal age at delivery and season of conception. In a separate cohort, nc886 imprinting was associated with lower body mass index in children at 5 y of age. Thus, we propose that the imprinting status of the nc886 DMR is "tunable" in that it is associated with maternal haplotype and prenatal environment. This provides a potential mechanism for transmitting information, with phenotypic consequences, from mother to child.

Original languageEnglish
JournalProceedings of the National Academy of Sciences of the United States of America
Volume115
Issue number51
Pages (from-to)E11970-E11977
Number of pages8
ISSN0027-8424
DOIs
Publication statusPublished - 18 Dec 2018

ID: 56422660