Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Mortality in women treated with assisted reproductive technology treatment - addressing the healthy patient effect

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Levels of and Changes in Childhood Body Mass Index in Relation to Risk of Atrial Fibrillation and Atrial Flutter in Adulthood

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Infertility in a Cohort of Male Danish Firefighters: A Register-Based Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. ASSOCIATIONS OF OCCUPANT MOTOR VEHICLE CRASH WITH FUTURE HEART FAILURE AND ISCHEMIC STROKE IN OLDER ADULTS

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Investigating Intestinal Glucagon after Roux-en-Y Gastric Bypass Surgery

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Genome-wide gene expression in a pharmacological hormonal transition model and its relation to depressive symptoms

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The clinical use of Anti-Müllerian Hormone in female reproduction.

    Research output: Book/ReportPh.D. thesisResearch

View graph of relations

Previous studies have reported reduced mortality among women undergoing assisted reproductive technology (ART) treatment, possibly related to selection of healthy women into ART treatment. The aim of this study was to explore the impact of relevant selection factors on the association between ART treatment and mortality and explore effect modification by parity. Women treated with ART in fertility clinics in Denmark during 1994-2009 (n = 42,897) were age-matched with untreated women from the background population (n = 204,514) and followed until ultimo 2010. With adjustment for relevant confounders, the risk of death was lower among ART-treated women immediately after ART treatment (HR = 0.68, 95% CI: 0.63, 0.74), but there was no apparent difference after 10 years (HR = 0.92, 95% CI: 0.79, 1.07). Having children prior to ART treatment was associated with a markedly reduced mortality (HR = 0.45, 95% CI: 0.38, 0.53), possibly due to better health among fertile women. While the frequency of previous medical and psychiatric diagnoses among ART-treated and untreated women was similar, differences in disease severity could explain the reduced mortality among ART-treated women, as poor prognosis would make ART treatment initiation unlikely. The survival advantage among ART-treated women is likely a selection rather than a biological phenomenon.

Original languageEnglish
JournalAmerican Journal of Epidemiology
Volume187
Issue number9
ISSN0002-9262
DOIs
Publication statusPublished - 1 Sep 2018

ID: 54357027